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Preparation method of controlled-release capsule with functions of detoxifying and diarrhea stopping

A slow-release capsule and antidiarrheal technology, which is applied in the directions of capsule delivery, medical preparations containing active ingredients, pharmaceutical formulations, etc. Therapeutic effect, the effect of improving drug efficacy

Inactive Publication Date: 2014-06-04
GUIZHOU BAIHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned extraction method is relatively simple, resulting in a large amount of ineffective ingredients and impurities in the product, and low bioavailability, making its clinical efficacy unsatisfactory

Method used

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  • Preparation method of controlled-release capsule with functions of detoxifying and diarrhea stopping
  • Preparation method of controlled-release capsule with functions of detoxifying and diarrhea stopping
  • Preparation method of controlled-release capsule with functions of detoxifying and diarrhea stopping

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Prescription: 1000g of Siza leaves.

[0082] Process:

[0083] ①Crush the opposite leaves into the coarsest powder, extract twice with 10 times the amount of 80% ethanol for 2 hours each time, filter, combine the extracts, recover the ethanol, concentrate to a relative density of 1.10-1.15 at 80°C Thick ointment; dregs are decocted twice with 10 times of water, 1.5 hours each time, filtered, combined extracts, and the filtrate is concentrated into a thick ointment with a relative density of 1.10-1.15 at 80°C; combined the above thick ointments, mixed well, Dried at 80°C, crushed through an 80-mesh sieve, and set aside;

[0084] ② Take 1 / 3 weight part of the powder in ① and add 20% of the powder weight by citric acid: Na 2 CO 3 =Effervescent disintegrant obtained by mixing 11:9, use 70% ethanol to make soft material, adjust the speed of the propeller to 30r / min, extrude the soft material through an extruder, and the extruded product is a curved strip under the action ...

Embodiment 2

[0090] Prescription: 1000g of Siza leaves.

[0091] Process:

[0092] ①Crush the opposite leaves into the coarsest powder, extract 3 times with 12 times the amount of 90% ethanol, each time for 1 hour, filter, combine the extracts, recover ethanol, concentrate to a relative density of 1.10-1.15 at 80°C Thick ointment; dregs are decocted with 12 times of water for 3 times, each time for 1 hour, filtered, combined extracts, and the filtrate is concentrated into a thick ointment with a relative density of 1.10-1.15 at 80°C; combined the above thick ointments, mixed well, Dried at 80°C, crushed through an 80-mesh sieve, and set aside;

[0093] ② Take 1 / 3 weight part of the powder in ① and add 30% of the powder weight by citric acid: Na 2 CO 3 = 15:5 mixed effervescent disintegrant, use 80% ethanol to make soft material, adjust the speed of the propeller to 30r / min, extrude the soft material through the extruder, and the extruded product is a curved strip under the action of gra...

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PUM

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Abstract

The invention discloses a preparation method of a controlled-release capsule with functions of detoxifying and diarrhea stopping. The controlled-release capsule is prepared from scabrid smallhooked hedyotis herb and auxiliary materials. According to the property of the scabrid smallhooked hedyotis herb, an extraction technology is optimized. Furthermore, aiming at the problem that the existing form bioavailability is low, one part of the scabrid smallhooked hedyotis herb is prepared into a quick-release pellet, the other part of the scabrid smallhooked hedyotis herb is prepared into a controlled-release pellet, and the two pellets are filled to prepare the capsule, so that the controlled-release capsule can be taken by patients in both of the acute stage and the chronic stage of colitis gravis, and therefore, the effect of treating both symptoms and root causes can be achieved, and the recurrence of the colitis gravis can be more effectively cured.

Description

technical field [0001] The invention relates to a preparation method of Jieduzhixie sustained-release capsules, belonging to the field of pharmaceutical technology. technical background [0002] Based on the understanding of the etiology and pathogenesis of chronic ulcerative colitis (UC), modern medicine mainly adopts anti-inflammatory, antibacterial, and immune response suppression methods. Commonly used drugs include aminosalicylic acid, corticosteroids, and immunosuppressants. , anti-infectives, etc. These drugs have played a positive role in the treatment of UC, but at the same time there are problems such as high recurrence rate, unsatisfactory treatment effect and serious side effects. [0003] Traditional Chinese medicine believes that the disease belongs to the category of "intestinal withdrawal", "dysentery" and "diarrhea". In clinical practice, compound prescriptions such as Pulsatilla Decoction and Xianglian Pills are often used for treatment. It has the advant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/74A61K9/48A61K9/16A61P1/12
Inventor 黄文荣马静李江
Owner GUIZHOU BAIHUA PHARMA
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