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Biomedical anti-corrosion porous compound material and preparation method thereof

A porous composite material and biomedical technology, applied in the field of biomedical devices, can solve the problems of reducing the ability of fracture fixation, reducing mechanical strength, etc., and achieve the effects of reducing corrosion rate, improving strength and toughness, and facilitating control.

Inactive Publication Date: 2013-01-30
CHONGQING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] (2) The degradation speed of magnesium alloy is fast. The biodegradation speed of magnesium alloy in the human body is too fast, and it often corrodes seriously before the fracture fixation and healing are not completely stable, and the excessive corrosion degradation speed will cause a significant decrease in mechanical strength and reduce the risk of fracture. The ability to fix, while the excessive release of magnesium ions and the high pH value triggers the excessive secretion of BMP-2, thereby activating osteoclasts, resulting in osteolysis
The invention uses porous magnesium alloy as the base to prepare composite bone repair material, and the composite material used is a polymer that can be used for bone repair. The composite bone repair material has the advantages of magnesium alloy, porous structure and polymer material, but at the same time They can overcome their respective shortcomings and have great application prospects in bone repair, but so far there are few research reports at home and abroad

Method used

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  • Biomedical anti-corrosion porous compound material and preparation method thereof
  • Biomedical anti-corrosion porous compound material and preparation method thereof
  • Biomedical anti-corrosion porous compound material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0070] Example 1: see Figure 4-5 and Figure 7-9 , a method for preparing a porous magnesium alloy medical composite material, comprising the steps of:

[0071] a. Preparation of porous magnesium alloy substrate by laser method

[0072] The substrate is AZ31 magnesium alloy (purchased commodity AZ31), the magnesium alloy is cut into AZ31 sheets of Φ12×3, and then the porous AZ31 substrate is prepared by laser drilling method. The pores are closed pores with a diameter of 100 μm and a depth of 100μm, porosity 30%, finally made into porous magnesium alloy substrate;

[0073] b, the method of porous magnesium alloy pretreatment layer:

[0074] Preparation of porous magnesium alloy oxide layer: prepare hydrogen peroxide with a concentration of 15%, soak the porous AZ31 substrate in hydrogen peroxide at room temperature for 2 seconds, and obtain an oxide layer on the surface and inside the pores of the porous magnesium alloy;

[0075] c. The method of porous AZ31 polymer lay...

Embodiment 2

[0084] The difference between this embodiment and embodiment 1 is as follows:

[0085] The difference in step 1) is:

[0086] a1 get magnesium-calcium alloy and magnesium-zinc alloy to prepare as-cast ternary magnesium alloy, in this as-cast ternary magnesium alloy, except magnesium element, the weight of calcium element and zinc element accounts for ternary magnesium alloy gross weight percentage and is 4%; The cast ternary magnesium alloy prepared in step a1 is made into an extruded ternary magnesium alloy at a temperature of 300-350°C;

[0087] a2 uses a laser drilling machine to drill holes in the extruded ternary magnesium alloy prepared in a1, with a pore diameter of 500 μm, a hole depth of 300 μm, and a porosity of 50%;

[0088] The difference in step 2) is that the prepared pretreatment layer is a phosphating layer, as follows:

[0089] Cleaning the porous magnesium alloy substrate prepared in step 1) with pure acetone until there are no impurities;

[0090] Then, s...

Embodiment 3

[0096] The difference between this embodiment and embodiment 1 is as follows:

[0097] The difference in step 1) is:

[0098] a1, get magnesium-calcium alloy and magnesium-strontium alloy to prepare as-cast ternary magnesium alloy, in this as-cast ternary magnesium alloy, except magnesium element, the weight of calcium element and strontium element accounts for ternary magnesium alloy gross weight percentage and is 4%, Extruded ternary magnesium alloy is made under the condition of 300-350℃;

[0099] a2, using a laser drilling machine to punch holes in the extruded ternary magnesium alloy prepared by a1, the hole diameter is 700 μm, the hole depth is 400 μm, and the porosity is 55%;

[0100] The difference in step 2) is that the prepared pretreatment layer is a phosphating layer, as follows:

[0101] First, clean the porous magnesium alloy substrate prepared in step 1) with pure alcohol or pure acetone until there are no impurities; soak in 5% sodium hydroxide solution for 1...

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Abstract

The invention relates to a biomedical anti-corrosion porous compound material and a preparation method thereof. The porous compound material is formed by a porous magnesium alloy base body, a pre-treating layer and a polymer coating, wherein the porous magnesium alloy base body is a magnesium-zinc alloy, a magnesium-calcium alloy, a magnesium-lithium alloy, a magnesium-strontium alloy with the magnesium content of more than 90% or a ternary system alloy formed by the systems; the pore diameter of the porous magnesium alloy base body is 100-1200 microns, the depth of a closed hole is 100-500 microns and the porosity is 30-70%; the pre-treating layer is an oxidized / phosphate layer and the thickness is 1-10 microns; and the polymer coating can be a degradable and aliphatic high molecular material layer and the thickness is 5-30 microns. The preparation method comprises the following steps of: preparing the porous magnesium alloy base body, and obtaining an oxidized film, which is taken as a middle layer of the subsequent polymer coating, on the surface of the porous magnesium alloy base body and in the hole; and coating a high molecular polymer layer. According to the biomedical anti-corrosion porous compound material and the preparation method thereof, the corrosion speed of the porous magnesium alloy base body is reduced and the toughness is improved.

Description

technical field [0001] The invention relates to orthopedic internal fixation materials in medical devices, belonging to the field of biomedical devices, in particular to a biomedical corrosion-resistant porous composite material that can be used for bone repair and a preparation method thereof. [0002] Background technique [0003] The repair of bone tissue injury has always been a major problem in clinical medicine. Bone injuries caused by natural disasters, traffic accidents, industrial injuries, sports trauma, bone tumor resection, metabolic osteoporosis (OP), and congenital bone diseases have become one of the major diseases that threaten people's health. At present, metal materials still play an important role in bone repair. Compared with ceramic materials and polymer materials, metals have high mechanical strength and fracture toughness, and are suitable for use in load-bearing areas. Applied metal biomaterials include stainless steel, cobalt-based alloys, titanium...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10C23C22/36
Inventor 黄美娜潘复生汤爱涛彭建潘虎成王丹丹姚丹丹韩梦娇
Owner CHONGQING UNIV
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