The invention discloses a novel nickel-chromium-cobalt-molybdenum high-temperature alloy seamless tube for a power station. The novel nickel-chromium-cobalt-molybdenum high-temperature alloy seamlesstube comprises the following components in percentage by weight: 0.03-0.10% of C, less than or equal to 1.0% of Si, less than or equal to 0.70% of Mn, less than or equal to 0.012% of P, less than or equal to 0.008% of S, 20.00-24.00% of Cr, 10.00-15.00% of Co, 0.70-1.50% of Al, 0.20-0.70% of Ti, 8.00-10.00% of Mo, less than or equal to 2.00% of Fe, less than or equal to 0.5% of Cu, 0.001-0.006% ofB, less than or equal to 0.005% of Pb, less than or equal to 0.005% of Sb, less than or equal to 0.001% of Bi, less than or equal to 0.010% of Sn, less than or equal to 0.010% of As and the balance Ni and trace elements, wherein the sum of the components is 100%. According to the nickel-chromium-cobalt-molybdenum high-temperature alloy seamless tube disclosed by the invention, a certain amount ofCo, Mo, B and other elements are added by controlling and limiting the components, a smelting process adopts vacuum induction and vacuum self-consumption, a tube manufacturing process adopts hot extrusion and full cold rolling, and finally solution treatment is performed; and by adopting the way, the alloy seamless tube has good structure stability, mechanical properties and process properties and can meet the using requirements of a heat exchange tube for the novel power station.