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Heat stable oil-in-water emulsion comprising oil containing polyunsaturated fatty acids

A technology of unsaturated fatty acid and oil-in-water emulsion, which is applied in the direction of emulsion delivery, antipyretics, and dispersion delivery, etc. It can solve problems such as demulsification and long thawing time

Active Publication Date: 2016-01-06
DSM IP ASSETS BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, freezing causes demulsification and requires a long thawing time before use

Method used

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  • Heat stable oil-in-water emulsion comprising oil containing polyunsaturated fatty acids
  • Heat stable oil-in-water emulsion comprising oil containing polyunsaturated fatty acids
  • Heat stable oil-in-water emulsion comprising oil containing polyunsaturated fatty acids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0158] The oil-in-water emulsion of the present invention is prepared as follows. Potassium sorbate (750 mg) and sodium sorbate (40.12 g) were added to water (558.54 g) and dissolved. The modified gum arabic (200.59 g) was added to the water mixture, then covered and slowly mixed (200 rpm) for 4-6 hours. Discard any foam that forms on top of the solution. After slow mixing, the pH of the water mixture was adjusted to pH=4 by adding an appropriate amount of citric acid. This water mixture is used as the base of the oil-in-water emulsion.

[0159] By combining and mixing Martek seaweed oil (40% DHA oil) (90 g, Martek Biosciences Corp., Columbia, Md.), rosemary extract (157.5 mg; rosemary OSR5%, 001280, Naturex Inc.) and taste masking agent (900mg, FlavorMasking599469AH, Firmenich, also known as MartekMasker) to prepare an oil mixture.

[0160] A portion of the water mixture (358.9 g) was placed in a high shear mixer and mixed at a speed of 6100 rpm while slowly adding the oil mix...

Embodiment 2

[0168] The oil-in-water emulsion of the present invention is prepared as follows. Potassium sorbate (730 mg) and sodium sorbate (38.74 g) were added to water (287.55 g) and dissolved. Add dextrose (169.49g) to the water mixture and dissolve, heat (if needed). The water mixture is then cooled (if necessary), and propylene glycol (193.7 g) is added to make the resulting water mixture uniform. The modified gum arabic (159.8 g) was added to the water mixture, then covered and slowly mixed (200 rpm) for 4-6 hours. Discard any foam that forms on top of the solution. After slow mixing, the pH of the water mixture was adjusted to pH=4 by adding an appropriate amount of citric acid.

[0169] A portion of the water mixture (394.9 g) was placed in a high shear mixer and mixed at a speed of 6100 rpm while slowly adding the oil mixture to provide an oil-in-water emulsion. During mixing, both the water mixture and the oil mixture were at 25°C.

[0170] Continue mixing until all the oil mixt...

Embodiment 3

[0177] The oil-in-water emulsion of the present invention is prepared as follows. Potassium sorbate (730 mg) and sodium ascorbate (38.74 g) were added to water (287.55 g) and dissolved. The modified gum arabic (159.8 g) was then added to the water mixture, then covered and slowly mixed (200 rpm) for 4-6 hours. Discard any foam that forms on top of the solution. After slow mixing, the pH of the water mixture was adjusted to pH=4 by adding an appropriate amount of citric acid. Then, glycerin (162 g) was added to the water mixture and the water mixture was mixed uniformly.

[0178] A portion of the water mixture (216.3 g) was placed in a high shear mixer and mixed at a speed of 6100 rpm while slowly adding the oil mixture to provide an oil-in-water emulsion. During mixing, both the water mixture and the oil mixture were at 25°C. Continue mixing until all the oil mixture is emulsified.

[0179] A front pressure of 15000 psi and a back pressure of 2000 psi were used to homogenize t...

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Abstract

The present invention relates to a thermally stable oil-in-water emulsion comprising: oil containing polyunsaturated fatty acids, water, an emulsifier, and a water-soluble stabilizer, and to a process for preparing said thermally stable oil-in-water emulsion . The thermally stable oil-in-water emulsion remained flowable at a temperature of -40°C and there was no change in particle size after storage at a temperature of -40°C to -15°C for 9 months.

Description

Technical field [0001] The present invention relates to a freezeable oil-in-water emulsion comprising an oil containing one or more polyunsaturated fatty acids, and the present invention relates to a method for preparing the freezeable oil-in-water emulsion . Background technique [0002] It has been shown that, among other benefits, polyunsaturated fatty acids ("PUFA", including long-chain PUFA "LC-PUFA") can enhance cognitive function and maintain cardiovascular health. In particular, ω-3 PUFA is an important dietary component to prevent arteriosclerosis and coronary heart disease, reduce inflammation and inhibit tumor cell growth, and ω-6 PUFA is very important, both as a structural lipid and as a precursor of, for example, prostaglandins and leukotrienes . PUFA is an important component of a healthy diet. However, since humans cannot synthesize PUFA in the endosome, these compounds must be ingested. For example, a variety of plants and animals (such as fish, walnuts, bilbe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/66C09K23/08C09K23/00C09K23/38C09K23/52C09K23/56
CPCA61K9/0095A61K9/19A61K9/107A61K31/20A61P25/00A61P29/00A61P35/00A61P9/00A61P9/10A61K9/48A61K8/92
Inventor 吉姆宾·麦麦柯·尼德汉姆苏钢韦·王-诺兰柴-平·查尔斯·许
Owner DSM IP ASSETS BV