78 results about "High-shear mixer" patented technology

The present invention is directed to a sustained release pharmaceutical composition in oral dosage form consisting essentially of a pharmaceutically effective amount of a medicament and a hydrophobic material in the absence of a lactose or hydrophobic carbohydrate polymer, said medicament being present in an amount greater than about 25% of the pharmaceutical composition and having a water solubility greater than about 1 gram per 10 mL of water at 25° C., said hydrophobic material having a melting point ranging from at least about 40° C. to about 100° C. at 1 atm pressure, and being present in an amount ranging from about 3% to about 20% by weight of the pharmaceutical composition and in an amount less than the of the medicament, and said hydrophobic material not being present in coating of said pharmaceutical composition; said pharmaceutical composition being prepared by direct compression in the absence of or melting the hydrophobic material or the use of high shear mixer. The present invention is also directed to a method of preparing said pharmaceutical composition.

A method for quickly forming a high value powdered feed materials, particularly pharmaceuticals, into small, durable granules using known elements of process equipment, comprising the steps of mixing the feed materials with a wetting solution in a high shear mixer or granulator, partially drying the granulated mixture in a first drying means to a state of intermediate dryness, milling the partially dried granulated product in a stream of air to create small partially dried granules of the desired physical size, and drying the product in the second drying means to the desired final Loss On Drying (LOD) percentage of wetting solution. The milled product may be conveyed by vacuum from the milling step to the second drying means through a relatively long cylindrical transfer hose to create uniformly rounded granules.

A diesel desulfurization method has various steps including: implementing a modified oxidative desulfurization (UAOD) process. The UAOD has the steps of: mixing diesel fuel with room temperature ionic liquid, oxidant, phase transfer catalyst, and acid catalyst in a tank in a mix; recycling the ionic liquid and recycling the acid catalyst in aqueous phase. A step is to move the sulfur from the diesel fuel in a fluidized bed reactor (FBR) having bed reactor material. The process can be improved with ultrasound during mixing, or a high shear mixer. The bed reactor is preferably acidic alumina for adsorbing oxidized sulfur. The oxidant is preferably hydrogen peroxide (H2O2). The acid catalyst is preferably a mixture of Acetic acid and Tri-fluoro acetic acid.

A durable, flexible, impermeable thermoplastic elastomer composition is produced using a dynamic vulcanization process conducted in a high shear mixer at elevated temperature. The composition comprises cured particles of a first halogenated isobutylene-containing elastomer and particles of a second elastomer having at least one functional group capable of reacting with and grafting to a polyamide, the particles of the first and second elastomers dispersed in a continuous thermoplastic polyamide matrix, the process comprising: (1) dispersing a curative in the halogenated elastomer and forming a pre-compounded, preferably pelletized composition; (2) introducing polyamide resin and optional stabilizers into the mixer and shearing and heating to melt the polyamide and form a mixture; (3) introducing a nylon plasticizer to reduce the viscosity of the polyamide mixture to substantially match that of the pre-compounded elastomer under mixing conditions; (4) introducing pellets of the pre-compounded elastomer into the mixer and initiating dynamic vulcanization of the elastomer and polyamide components; (5) introducing the second elastomer and continuing heating and shearing to disperse the second elastomer and substantially complete dynamic vulcanization; and delivering the thermoplastic elastomer composition from the mixer. Such compositions are particularly useful in applications such as tire inner liners and barrier films or layers.

A method for the control of insects breeding on water surfaces and particularly mosquitoes, comprising blending in a high shear mixer water, the ester of a fatty acid of 10 to 25 carbon atoms and a low molecular weight alcohol, such as methanol or ethanol, an emulsifying agent and a thickener until an emulsion containing the ester with droplet sizes ranging from 1 to 20 microns in diameter is obtained and applying such to the surface of insect infested water in sufficiently diluted form, to break the emulsion and form a thin continuous film.

In a process for the production of a silicone in water emulsion in which a polysiloxane fluid, at least one surfactant and water are continuously fed to a high shear mixer in such proportions as to form a viscous oil in water emulsion which is continuously withdrawn from the mixer. The polysiloxane fluid may be a non-reactive fluid or may have reactive groups capable of taking part in a chain extension reaction. A desired emulsion particle size can be maintained by monitoring the pressure in the supply line at the inlet to the high shear mixer.