Qianxi capsule and preparation method thereof

A technology of Qianxi capsules and capsules, applied in the field of medicine, can solve the problems of complicated auxiliary material process, affecting the coating process, poor friability of plain tablets, etc., and achieve the effects of large evaporation surface area, short heating time and low hygroscopicity

Active Publication Date: 2013-03-13
江西欧氏药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology optimizes the production processes involved during making hard shells containing medications called Quanxi Capsules (QC). By reducing excessive material usage while maintaining their effectiveness at delivering medicine through an easy way, this method reduces costs compared to traditional methods such as tablets or powders. Additionally, it improves the stability and dissolution rate of these drugs when delivered into patients' blood vessels without losing them altogether.

Problems solved by technology

This patented technical problem addressed in this patents is finding a more efficient way to produce Quarns containing various active ingredients including Diodecylindne, Thympanolum Gaster Root, Salvia Mini Gentilaceans, Triterpenoid Compound A, Natural Killer Aggren Syndrome Viruses, Cyclopsylic Acridothera Colletaeceae, Helicosynthes Family Gastropodidae, Schizome Fever, Rhadinopsis Semitectina Hymenocharis Group, Symbiochemistry Research Center National Committee Tobacco Laboratories' Patent describes different methods for producing quarts containing these beneficial agents.

Method used

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  • Qianxi capsule and preparation method thereof
  • Qianxi capsule and preparation method thereof
  • Qianxi capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 A kind of preparation method of Qianxi Capsule

[0027] Take Andrographis paniculata 40g and pulverize into fine powder, sieve; 1960 grams of Andrographis paniculata and 2000 grams of Senecio are pulverized into coarse powder, soak with 1.2% sodium hydroxide solution in right amount overnight, add water to percolate, flow rate is 3ml / min per kilogram of medicinal material, collect Percolate about 1000ml, add 1 / 7 amount of saturated saline, then adjust the pH to about 2-3 with hydrochloric acid, stir well, let it stand for 12 hours, discard the supernatant, collect the precipitate, spray dry; add the Andrographis paniculata Fine powder, 30 grams of starch, 7.5 grams of gelatin, mixed evenly, made into granules, dried, filled with 1000 capsules, packed in aluminum-plastic.

Embodiment 2

[0028] Embodiment 2 A kind of preparation method of Qianxi Capsule

[0029] Take 40g of Andrographis paniculata and crush it into fine powder, sieve; the remaining 1960g of Andrographis paniculata and 2000g of Senecio are crushed into coarse powder, soak overnight with an appropriate amount of 1.3% sodium hydroxide solution, add water to percolate at a flow rate of 5ml / min per kilogram of medicinal material, collect Percolate about 1000ml, add 1 / 7 amount of saturated saline, then adjust the pH to about 2-3 with hydrochloric acid, stir well, let it stand for 12 hours, discard the supernatant, collect the precipitate, spray dry; add the Andrographis paniculata Fine powder, 28 grams of starch, 7 grams of gelatin, mixed evenly, made into granules, dried, filled with 1000 granules, and packed in aluminum-plastic.

Embodiment 3

[0031] 3.1 Materials

[0032] Bacteria: Staphylococcus aureus (26003), Escherichia coli (44103), typhoid bacillus (0602-10), Yersinia (52301-5), Shigella dysenteriae (1507-2), Shigella baumannii (51583), Shigella flexneri (51571) (the above strains were all obtained from the China Institute for the Control of Pharmaceutical and Biological Products, Ministry of Health), and Streptococcus B (from the Baozhi strains of the Department of Microbiology, Jiangxi University of Traditional Chinese Medicine).

[0033] Test substance: Qianxi Capsule

[0034] 3.2 Method

[0035] Suspend Qianxi Capsules in 100ml broth, dilute the drug according to the double dilution method, and use the other tube without drug as a control, and dilute the cultures of 9 bacterial strains cultivated for 6 hours to 10 -4 , each tube was inoculated with 0.1ml, incubated for 24 hours, then inoculated in a flat container, incubated at 37°C for 24 hours, determined whether there were colonies, and measured the ...

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Abstract

The invention discloses a qianxi capsule and a preparation method thereof. The capsule is composed of Andrographis paniculata Nees and senecio according to a certain proportion. The preparation method comprises taking a part of the Andrographis paniculata Nees, crushing into fine powder, and sieving; crushing the residual Andrographis paniculata Nees and the senecio into crude powder, percolating, processing the percolating liquid, collecting deposition, and spray drying; adding the above Andrographis paniculata Nees fine powder, starch and proper amount of gelatin, uniformly mixing, preparing into particles, drying and filling to obtain the finish product. The qianxi capsule is safe and effective, has efficacies of clearing away heat and detoxifying, diminishing inflammation and relieving pain and stopping diarrhea shown by pharmacological and clinical studies, and can be clinically used for treating enteritis, colitis, bacterial dysentery, nasosinusitis, etc.

Description

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Claims

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Application Information

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Owner 江西欧氏药业有限责任公司
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