Method for preparing molecular device with surficial biomolecules removed and based on graphene electrodes

Abstract

The invention discloses a method for preparing a molecular device with surficial biomolecules removed and based on graphene electrodes. The method includes: (1) preparing a graphene transistor device array, wherein the conducting channel in the graphene transistor device array is the grapheme, a channel is arranged on the grapheme, DNA sequence connecting parts with lengths of 1-10nm are arranged on the channel at an interval and perpendicular to the sources and the drains in the graphene transistor devices; (2) soaking a molecular connecting device of the graphene electrodes in TritonX-100 for 0.5-3h; and connecting a designed DNA sequence into nano gaps to obtain the DNA unimolecular connecting device. The prepared unimolecular connecting device based on the graphene electrodes is used for electrical signal detection, a control experiment is set simultaneously, a detection result proves that the biomolecules on the surface of the molecular device of the graphene electrodes can be removed effectively, and the detection accuracy can be improved.

Description

technical field [0001] The present invention relates to a method for preparing molecular devices based on graphene electrodes for removal of surface biomolecules. Background technique [0002] Graphene is an emerging two-dimensional planar material with many excellent properties, such as its high strength, high electron mobility and thermal conductivity (Geim, A.K.; Novoselov, K.S.Nature.Mater.2007, 6, 183.). Graphene can be used as an ideal electrode material due to its good electrical conductivity and chemical stability. We have established a method to construct single-molecule devices by connecting one or several molecules between the nano-gap of graphene through strong amide bonds. The graphene molecular device can not only effectively connect DNA molecules, but also withstand external stimuli. (1: Guo, X. et al. Science, 2006, 311, 356. 2: Guo, X. et al. Nano Lett., 2007, 7, 1119. 3: Guo, X., Gorodetsky, A.A., Hone, J., Barton , J.K., Nuckolls, C. Nat. Nanotechnol. 2...

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a method for preparing molecular devices based on graphene electrodes that remove surface biomolecules, to overcome the remaining biomolecules on the surface of graphene electrodes in existing preparation methods

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