Application of Aphanamixoid A for preparing human fungal resistant medicine

A technology against human fungi and drugs, applied in the directions of antifungal agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of digestive tract irritation, strong accumulation of toxicity, etc. active effect

Inactive Publication Date: 2013-03-27
何晓涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots

Method used

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  • Application of Aphanamixoid A for preparing human fungal resistant medicine
  • Application of Aphanamixoid A for preparing human fungal resistant medicine
  • Application of Aphanamixoid A for preparing human fungal resistant medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of compound Aphanamixoid A tablet involved in the present invention:

[0014] Get 20 grams of compound Aphanamixoid A, add 180 grams of conventional adjuvants for preparing tablets, mix evenly, and make 1000 tablets on a conventional tablet press.

Embodiment 2

[0015] Embodiment 2: the preparation of compound Aphanamixoid A capsules involved in the present invention:

[0016] Get 20 grams of compound Aphanamixoid A, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0017] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0018] Experimental example: Anti-fungal activity of Aphanamixoid A in humans

[0019] Anti-human fungus activity experiment is the method of concentration dilution, each determination is repeated three times, the test pathogens include Trichomonas rubrum, Microsporum lanoides and Phytophthora clematis, and the concentration of the bacterial solution is 10 5 individual / mL. The initial concentration of Aphanamixoid A is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), serially diluted to 0.098 μg / mL, and the equal volume of bacterial liquid and test samples are mixed and cultured in a 96-well plate, and the human fungal culture temperature 28 ℃ respectively, observe after 24 hours of incubation time, if no colony is found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the results of Aphanamixoid A against human fungi are shown in Table 1.

[0020] Table 1 MIC value of Aphanamixoid A...

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Abstract

The invention relates to application of Aphanamixoid A for preparing a human fungal resistant medicine, belonging to the field of medicines. Aphanamixoid A has strong effects on inhibiting trichophyton rubrum, microsporum lanosum or trichophyton tonsurans, therefore, Aphanamixoid A can be used as a human fungal resistant compound and is hopeful to be used for preparing related medicines. The application of Aphanamixoid A for preparing the human fungal resistant medicine is disclosed for the first time; because the skeleton type belongs to a brand new skeleton type and the human fungal inhibitory activity of Aphanamixoid A is strong unexpectedly, the possibility that other compounds give any inspiration does not exist; Aphanamixoid A has outstanding substantive characteristics; and simultaneously, Aphanamixoid A has obvious progress for preventing and treating human fungal infection.

Description

technical field [0001] The present invention relates to the application of Aphanamixoid A, in particular to the application of Aphanamixoid A in the preparation of antifungal drugs for human body. Background technique [0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots. [0003] The compound Aphanamixoid A ...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P31/10
Inventor 何晓涛
Owner 何晓涛
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