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Pharmaceutical composition for preventing ONFH (Osteonecrosis of Femoral Head) after child DDH (Developmental Dysplasia of Hip) operation

A technology for necrosis of the femoral head and hip joint, which can be used in drug combinations, bone diseases, pharmaceutical formulations, etc., to solve problems such as loosening of internal fixation and fracture of internal fixation, and to achieve exact curative effects and prevent necrosis of the femoral head.

Active Publication Date: 2014-03-19
NANTONG HONGCI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4. Internal fixation fracture: internal fixation loosening may occur after surgery, and internal fixation may break due to trauma and other reasons

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation of embodiment 1 Chinese medicine granules

[0034] The first step, prepare clear cream powder:

[0035] 1) Preparation of materials: Weigh 2 kg of cleaned burdock seeds and 1 kg of chuanxiong according to the prescription, and set aside;

[0036] 2) Decoction: add water for decoction, add water to each pot for the first decoction, which is 8 times the total amount of medicinal materials, heat and boil for 3 hours, and the extract is filtered through a 200-mesh filter and enters the sedimentation tank; for the second decoction, add 4 times the amount of medicinal materials The water is heated and extracted, kept boiling for 3 hours, and the extract is filtered through a 200-mesh filter and enters the sedimentation tank;

[0037] 3) Precipitation: The extract in the precipitation tank is precipitated for 24 to 36 hours, and the supernatant is filtered through a 200-mesh filter into a three-effect evaporator, and the precipitate is treated as waste;

[00...

Embodiment 2

[0043] The preparation of embodiment 2 Chinese medicine oral liquid

[0044] 1) Preparation of materials: Weigh 3 kg of cleaned burdock seeds and 1 kg of chuanxiong according to the prescription, and set aside;

[0045] 2) Decoction: add water for decoction, add water to each pot for the first decoction, which is 8 times the total amount of medicinal materials, heat and boil for 3 hours, and the extract is filtered through a 200-mesh filter and enters the sedimentation tank; for the second decoction, add 4 times the amount of medicinal materials The water is heated and extracted, kept boiling for 3 hours, and the extract is filtered through a 200-mesh filter and enters the sedimentation tank;

[0046]3) Precipitation: The extract in the precipitation tank is precipitated for 24 to 36 hours, and the supernatant is filtered through a 200-mesh filter into a three-effect evaporator, and the precipitate is treated as waste;

[0047] 4) Concentration: When the supernatant is concen...

Embodiment 3

[0051] Example 3 Study on the curative effect of the medicine of the present invention combined with surgery in the treatment of developmental dislocation of the hip in children

[0052] 34 cases of children with developmental dislocation of the hip, aged 2 to 14 years, with an average age of 7.1 years, all of them were developmental dislocation of the hip. Sometimes the affected limb shortens and limps. If bilateral dislocation occurs, the hips are shrugged after standing, the waist is protruding forward, and the walking is like a duck step; (2) Deformity: Compared with the normal lower limbs, the unilateral affected limb is shortened and deformed, often adducting deformed, and abducted (3) Upward movement of the greater trochanter: the top point of the greater trochanter in the child moves up, exceeding the Nelaton line by more than 1cm. All patients were randomly divided into test group and control group, and there was no significant difference in age and condition between...

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Abstract

The invention discloses a pharmaceutical composition for preventing ONFH (Osteonecrosis of Femoral Head) after a child DDH (Developmental Dysplasia of Hip) operation, relating to the technical field of traditional Chinese medicine. The pharmaceutical composition for preventing ONFH after DDH operation is prepared from traditional Chinese medicinal materials in parts by weight of: 15-30 parts of achene of great burdock and 8-13 parts of ligusticum wallichii. The pharmaceutical composition cooperates with an operation to treat the DDH, so that the pharmaceutical composition can prevent occurrence of ONFH efficiently, achieves exact curative effects and is worth popularizing clinically.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a pharmaceutical composition for preventing postoperative femoral head necrosis in children with developmental dislocation of the hip. Background technique [0002] Developmental Dysplasia of the Hip (DDH) is a disease in which unilateral or bilateral hip joints are unstable and the femoral head and acetabulum are malaligned due to factors such as genetics, breech presentation, and leg binding. . Early reduction can restore the normal anatomical relationship of the femoral head in time, which is conducive to development and can increase the stability of the hip joint. It is generally considered that the treatment effect is best within one year of age. In the treatment of children with developmental dislocation of the hip, pelvic and femoral deformities must be corrected at the same time, and combined surgery can achieve good results. However, the operation...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61P19/08
Inventor 葛晓芬张学梅
Owner NANTONG HONGCI PHARMA
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