Ultrahigh-molecular weight polyethylene composite material for artificial joint and preparation method of ultrahigh-molecular weight polyethylene composite material

An ultra-high molecular weight, artificial joint technology, applied in the field of ultra-high molecular weight polyethylene composite materials for artificial joints and their preparation

Active Publication Date: 2014-08-20
NANJING UNIV OF SCI & TECH
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004]However, the existing research only considered the surface modification of the existing UHMWPE block joint materials, the thickness of the surface grafted polymer layer It is nanoscale, about 100nm [T.Moro, Y.Takatori, M.Kyomoto, et al. Surface grafting of biocompatible phospholipid polymer MPC provides wear resistance of tibial polyethylene insert in artificial knee joints. Osteoarthritis and Cartilage, 2010,18: 1174-1182. Cartilage-mimicking, High-density Brush Structure Improves Wear Resistance of Crosslinked Polyethylene. Clinical Orthopedic and Related Research, 2011, 469: 2327-2336.]

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0019] A method for preparing an ultrahigh molecular weight polyethylene composite material for artificial joints of chimeric polymer macromolecular chains provided by the invention comprises the following steps:

[0020] 1. Put the ultra-high molecular weight polyethylene powder in a benzophenone (5-20mg / ml) solution and let it stand in the dark for 5-40 minutes, and then dry it in a vacuum in the dark. The ultra-high molecular weight polyethylene powder is medical grade. The molecular weight is above 1.5 million, and the diameter is 13-270 μm;

[0021] 2. Add ultra-high molecular weight polyethylene powder coated with a photosensitizer on the surface to the monomer solution to be grafted, stir evenly, and irradiate with ultraviolet light for 10-90 minutes. After the irradiation, the powder is washed and dried, wherein the monomer The body has good biocompatibility, and can be acrylic acid, 2-methacryloyloxyethyl phosphorylcholine (MPC), N-vinylpyrrolidone, acrylamide, ...

Embodiment 1

[0027]The ultra-high molecular weight polyethylene powder with a diameter of 270 μm was immersed in an acetone solution of benzophenone (10 mg / ml), allowed to stand for 5 min, and then dried in vacuum in the dark. Add the powder coated with the photosensitizer into the acrylamide monomer solution, place it on a magnetic stirrer and mix evenly, and irradiate with 500W ultraviolet light for 80 minutes in a nitrogen protective atmosphere to obtain superhigh Molecular weight polyethylene powder. The grafted powder material was washed with ethanol and dried in vacuum. Put the above powder material into the mold, under vacuum conditions (-0.1MPa), 190°C, hot pressing pressure 12MPa, heat preservation and pressure holding for 1.5h, cooling and demoulding to take out the sample.

[0028] A pin-on-disc friction tester was used to test the tribological properties. Under normal saline lubrication conditions, the friction coefficient of the samples decreased from 0.054 before grafting t...

Embodiment 2

[0030] The ultra-high molecular weight polyethylene powder with a diameter of 100 μm was immersed in a diethyl ether solution of benzophenone (5 mg / ml), allowed to stand for 20 min, and then dried under vacuum in the dark. Add the powder coated with the photosensitizer into the acrylic acid monomer solution, place it on a magnetic stirrer, stir and mix evenly, and irradiate with 500W ultraviolet light for 10 minutes in a nitrogen protective atmosphere to obtain an ultra-high molecular weight polymer grafted with acrylic acid macromolecular chains. vinyl powder. The grafted powder material was washed with ethanol and dried in vacuum. The above powder material and pure ultra-high molecular weight polyethylene block are layered into the mold, under vacuum conditions, 150 ° C, hot pressing pressure 7.5 MPa, heat preservation and pressure holding time 2.5 h. Cool and demould to take out the sample.

[0031] Using a pin-on-disk friction tester and a reciprocating friction tester, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
diameteraaaaaaaaaa
wavelengthaaaaaaaaaa
Login to view more

Abstract

The invention discloses an ultra-high molecular weight polyethylene composite material for artificial joints and a preparation method thereof. The artificial joint composite material is formed by embedding polymer macromolecular chains and ultra-high molecular weight polyethylene powder, and is made of the composite material The artificial joint has uniformity as a whole. The polymer macromolecular chain embedded in it significantly improves the biocompatibility and tribological performance of the artificial joint, and reduces tissue reaction and aseptic loosening. The artificial joint prepared by the invention and the method has the characteristics of long-lasting low friction and wear resistance, and can prolong its service life.

Description

technical field [0001] The invention relates to an ultra-high molecular weight polyethylene composite material for artificial joints with chimeric polymer macromolecular chains and a preparation method thereof, in particular to an artificial joint capable of maintaining good wear resistance under long-term friction and wear composite material. Background technique [0002] Ultra-high molecular weight polyethylene (UHMWPE) has excellent comprehensive properties such as impact resistance, low temperature resistance, wear resistance, chemical corrosion resistance, and self-lubrication, and is currently widely used as an artificial joint material. Clinical experiments have found that the artificial joint composed of ultra-high molecular weight polyethylene as the acetabular cup and femoral head parts made of hard materials such as metal will produce a large amount of wear debris during long-term use, especially the acetabular cup. The polyethylene wear debris accumulates and in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/16A61L27/14C08F255/02C08F2/48
Inventor 熊党生邓亚玲王琨
Owner NANJING UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap