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Vaccine failure indication label based on color change caused by temperature and preparation method thereof

A vaccine and indicator technology, applied in chemical instruments and methods, material analysis by observing the impact on chemical indicators, thermometers, etc., can solve the problems of vaccines that cannot be used and cannot be identified.

Inactive Publication Date: 2015-01-28
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adhere this label on the vaccine packaging box or vaccine bottle. When the vaccine is stored at 2-8°C, its appearance is an identifiable barcode label. When the vaccine is exposed above 8°C, the temperature-changing label will irreversibly discolor. The entire surface of the barcode will be stained with blue, so that the barcode reader cannot recognize the label, indicating that the vaccine is invalid and cannot be used

Method used

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  • Vaccine failure indication label based on color change caused by temperature and preparation method thereof
  • Vaccine failure indication label based on color change caused by temperature and preparation method thereof
  • Vaccine failure indication label based on color change caused by temperature and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Preparation of microcapsules

[0027] (1) Preparation of emulsion:

[0028] Preparation of sodium alginate solution: Take 90 parts of water, put it in a three-necked flask, and add 10 parts of sodium alginate solid evenly while stirring under the condition of a constant temperature water bath at a temperature of 30~60°C to fully dissolve it, and obtain 10% sodium alginate solution.

[0029] Preparation of monoglyceride solution: Take 1 part of monoglyceride solid, add 99 parts of water, stir to fully dissolve it in a constant temperature water bath at a temperature of 90°C, and obtain a monoglyceride solution with a mass fraction of 1%.

[0030] Mix 2.5 parts of monoglyceride solution, 5 parts of dodecyl alcohol or decanyl alcohol, 0.5 parts of Tween-80 and 92 parts of sodium alginate solution, and stir for 20 minutes at a rotational speed of 1500 r / min to obtain Lotion required.

[0031] (2) Preparation of coagulation bath

[0032] Get 5 parts of chitosan and 5 ...

Embodiment 2

[0042] 1. Preparation of microcapsules

[0043] (1) Preparation of emulsion:

[0044] Preparation of sodium alginate solution: Take 95 parts of water, put it in a three-necked flask, and add 5 parts of sodium alginate solid evenly while stirring under the condition of a constant temperature water bath at a temperature of 50°C to fully dissolve it to obtain the mass fraction 5% sodium alginate solution.

[0045] Preparation of monoglyceride solution: Take 6 parts of monoglyceride solid, add 94 parts of water, and stir to fully dissolve it in a constant temperature water bath at a temperature of 80°C to obtain a monoglyceride solution with a mass fraction of 6%.

[0046] Mix 6 parts of monoglyceride solution, 3 parts of dodecyl alcohol or decanyl alcohol, 0.5 part of Tween-80 and 90.5 parts of sodium alginate solution, and stir for 50 minutes at a rotating speed of 5000 r / min to obtain Lotion required.

[0047] (2) Preparation of coagulation bath

[0048]Get 2 parts of chito...

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Abstract

The invention provides a preparation method for a vaccine failure indication label based on color change caused by temperature. The label can be used for effectively detecting if a vaccine is out of action in the storage, transportation and operation processes. When the vaccine is in an environment of 2-8 DEG C, a general black strip code mark is displayed on the label; and when the vaccine is in the environment of more than 8 DEG C, a strip code on the label is dip-dyed, becomes blue irreversibly and cannot be identified by a strip code identifier, so that the situation shows that the vaccine is exposed for a period of time in the high-temperature environment, and the purpose of indicating if the vaccine is out of action is achieved. The vaccine failure indication label is simple and convenient to prepare, is practical and can be used for effectively indicating if the vaccine is out of action in the transportation and storage processes so as to guarantee the safety of vaccination.

Description

technical field [0001] The invention relates to a preparation method of a temperature-induced discoloration-based vaccine expiration indicator label. Background technique [0002] The state stipulates that vaccines and other biological products must be stored and transported under refrigerated conditions, the purpose of which is to maximize the effectiveness of vaccines. For vaccines, the most important impact of temperature on vaccines is its stability and effectiveness. All kinds of vaccines used for vaccination are sensitive to heat and light, and most vaccines are relatively stable in a cool and dark place at 2-8°C. [0003] Since vaccines are sensitive to temperature, proper refrigeration equipment should be installed throughout the process from production, storage, transportation, distribution to use of vaccines, so that vaccines are always placed in the specified low-temperature refrigeration state to ensure that the reasonable potency of vaccines is not affected. d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/78G01K11/16G09F3/02B32B37/12
Inventor 陈蕴智张正健王欣刘明张德森魏丹妹
Owner TIANJIN UNIV OF SCI & TECH
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