Application of mental treasure pills in preparation of medicine for treating senile dementia

A technology of Naolibao pills and Alzheimer's disease, which is applied in the field of medicine, can solve the problems such as the improvement of learning and memory function of spatial cognitive impairment in Naolibao pills, and achieve the effect of safe medication, low price, and less toxic and side effects

Inactive Publication Date: 2013-05-15
广东万年青制药股份有限公司
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

Its clinical application and main component research progress suggest that it may be suitable for the treatment of senile dementia, but there is no report on the improvement of spatial cognitive impairment and learning and memory function of Naolibao pills, and it is used for systematic experimental research and clinical research on the prevention and treatment of senile dementia There is no report

Method used

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  • Application of mental treasure pills in preparation of medicine for treating senile dementia
  • Application of mental treasure pills in preparation of medicine for treating senile dementia
  • Application of mental treasure pills in preparation of medicine for treating senile dementia

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Embodiment Construction

[0012] In order to better understand the technology of the present invention, and understand the mechanism and essence of Naolibao Pills’ effective prevention and treatment of senile dementia, the inventors improved the animal model of memory acquisition impairment in Naolibao Pills—the scopolamine-induced mouse memory acquisition impairment senile dementia model. , Improving the animal model of memory consolidation impairment——NaNO 2 In-depth studies have been carried out on the mouse model of memory consolidation impairment senile dementia, the animal model of improving memory reproduction impairment - 40% ethanol-induced mouse memory reproduction impairment senile dementia model, and the APP / PS1 double transgenic model mice.

[0013] experimental animals

[0014] SPF grade Kunming mice, weighing 18-22g, half male and half male, certificate number: Yue Jian Zheng Zi 2011-0029, animal experiment license number: SYXX (Guangdong) 2007-0081. SPF grade APP / PS1 mice, 25 females a...

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Abstract

The invention discloses application of mental treasure pills in preparation of a medicine for treating senile dementia. Due to the improvement effect of the mental treasure pills on mouse reproduction memory disorder caused by scopolamine and mouse memory consolidating hinder caused by NaNO2 and mouse reproduction memory disorder caused by ethanol through a step-down test and a Morris water maze test, the mental treasure pills have a certain effect of improving the learning and memory. In addition, the Morris water maze test of APP/PSI double transgenic mice further proves that the mental treasure pills have a certain effect of improving the dysmnesia. The experimental result proves that the mental treasure pills can be used for preparing the medicine for treating senile dementia and have the characteristics of stable curative effect, medication safety, low toxic-side effect, low price and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Naolibao pills in the preparation of medicines for preventing and treating senile dementia. Background technique [0002] Alzheimer's disease (AD) is a degenerative disease of the central nervous system mainly characterized by progressive cognitive impairment and memory impairment. The main pathological features are brain atrophy, senile plaques in brain tissue, cerebral vascular deposits and Neurofibrillary tangles. With the increase of average human life expectancy, Alzheimer's disease has become one of the main diseases that threaten the quality of life of human beings in old age, and its incidence is increasing year by year, and about 70% of Alzheimer's diseases are AD. Since the etiology of AD has not been fully elucidated, there is no specific treatment drug. [0003] Currently, commonly used drugs for the treatment of AD include acetylcholinesterase...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61K9/20A61P25/28A61K31/355
Inventor 欧先涛沈晓燕
Owner 广东万年青制药股份有限公司
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