Gastrodin injection preparation and preparation method
A gastrodin injection and preparation technology, applied in the field of medicine, can solve the problems of increasing the risk of clinical use, adverse reactions, patient pain, etc., and achieve the effects of facilitating drug absorption, reducing body stimulation, and simplifying prescriptions
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[0025] Example 1:
[0026] A Tianma injection preparation includes the following components in weight percentage:
[0027]
[0028] The preparation method is as follows:
[0029] (1) Weigh 70% of the water for injection of the formula and cool it to 30-40℃;
[0030] (2) Weigh the metal ion complexing agent disodium calcium edetate and dissolve it in step (1) cooled water for injection;
[0031] (3) Weigh the formula amount of gastrodin and dissolve it in the solution obtained in step (2). After the dissolution is complete, add the formula amount of stabilizer sodium chloride;
[0032] (4) Use disodium hydrogen phosphate-sodium dihydrogen phosphate buffer to adjust the pH value in the range of 5.0 to 7.0 for the solution obtained in step (3);
[0033] (5) Add the solution obtained in step (4) to 0.1wt% activated carbon, stir and stand for 15 minutes to absorb, filter and decarburize, supplement the water for injection, fill with nitrogen, potting, and sterilize at 121°C for 15 minutes, tha...
Example Embodiment
[0034] Example 2:
[0035] A Tianma injection preparation includes the following components in weight percentage:
[0036]
[0037]
[0038] The preparation method is as follows:
[0039] (1) Weigh 70% of the water for injection of the formula and cool it to 30-40℃;
[0040] (2) Weigh the metal ion complexing agent disodium calcium edetate and dissolve it in step (1) cooled water for injection;
[0041] (3) Weigh the formula amount of gastrodin and dissolve it in the solution obtained in step (2). After the dissolution is complete, add the formula amount of stabilizer sodium chloride;
[0042] (4) Use disodium hydrogen phosphate-sodium dihydrogen phosphate buffer to adjust the pH value in the range of 5.0 to 7.0 for the solution obtained in step (3);
[0043] (5) Add the solution obtained in step (4) to 0.1wt% activated carbon, stir and stand for 15 minutes to absorb, filter and decarburize, supplement the water for injection, fill with nitrogen, potting, and sterilize at 121°C for 15 min...
Example Embodiment
[0044] Example 3:
[0045] A Tianma injection preparation includes the following components in weight percentage:
[0046]
[0047] The preparation method is as follows:
[0048] (1) Weigh 70% of the water for injection of the formula and cool it to 30-40℃;
[0049] (2) Weigh the metal ion complexing agent disodium edetate and dissolve it in step (1) cooled water for injection;
[0050] (3) Weigh the formula amount of gastrodin and dissolve it in the solution obtained in step (2). After the dissolution is complete, add the formula amount of stabilizer sodium sulfite;
[0051] (4) Use acetic acid-sodium acetate buffer to adjust the pH value of the solution obtained in step (3) within the range of 5.0 to 7.0;
[0052] (5) Add the solution obtained in step (4) to 0.1wt% activated carbon, stir and stand for 15 minutes to absorb, filter and decarburize, supplement the water for injection, fill with nitrogen, potting, and sterilize at 121°C for 15 minutes, that is Get gastrodin injection.
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