Solution concentration of nadroparin calcium determined by phenanthroline-zinc sulfate ultraviolet spectroscopy

A technology of phenanthroline and ultraviolet spectroscopy, which is applied in the field of rapid quantitative determination of the concentration of nadroparin calcium solution, can solve problems such as inability to apply and large analytical errors, and achieve the effect of good anti-interference ability.
CN103149170BActive Publication Date: 2015-01-21SHENZHEN SCIPROGEN BIO PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENZHEN SCIPROGEN BIO PHARMA
Publication Date
2015-01-21

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Abstract

The invention discloses solution concentration of nadroparin calcium determined by phenanthroline-zinc sulfate ultraviolet spectroscopy. Under the environment of buffered solution, Ultraviolet absorbance degrees of mixed solution which includes Zn2+ions, phenanthroline and the nadroparin calcium are determined, and then the concentration of the nadroparin calcium is determined by quantity. According to the solution concentration of the nadroparin calcium determined by the phenanthroline-zinc sulfate ultraviolet spectroscopy, a phenanthroline-zinc sulfate ultraviolet spectroscopy test system is applied, quick quantitative determination of the solution concentration of the nadroparin calcium can be achieved. The linear range of an analytical method of the solution concentration of the nadroparin calcium determined by the phenanthroline-zinc sulfate ultraviolet spectroscopy is 1.184%-16.33%, meanwhile, the analytical method of the solution concentration of the nadroparin calcium determined by the phenanthroline-zinc sulfate ultraviolet spectroscopy has good anti-jamming capability and can be applied in the practical production process of nadroparin calcium medicines and capable of carrying out concentration determination to intermediate product solution or finished product solution.
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Description

technical field

[0001] The invention belongs to the production field of nadroparin calcium medicine, and in particular relates to a method for rapidly and quantitatively measuring the concentration of nadroparin calcium solution by using o-phenanthroline-zinc sulfate ultraviolet spectroscopy. Background technique

[0002] Heparin is a mucopolysaccharide sulfate composed of D-glucosamine, L-iduronic acid, N-acetylglucosamine and glucuronic acid alternately, with a molecular weight from 5 to 30kDa, of which the sulfate radical accounts for about 40%. Typically, heparins originate primarily from porcine and bovine intestinal mucosa and lungs. In today's medicine, heparin is mainly used as an anticoagulant. It was officially used in clinical treatment in 1953 and is considered to be the most effective and clinically used anticoagulant drug. Unfractionated Heparin was initially used. By the end of the last century, unfractionated heparin was prepared into heparin derivatives w...

Claims

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