Compound antihypertensive drug composition

A compound and pharmaceutical technology, applied in the field of medicine, can solve the problems of no inhibition of myocardial contractility, no membrane stability, etc.

Inactive Publication Date: 2013-06-26
CHINA RESOURCES DOUBLE CRANE PHARMA COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No endogenous sympathomimetic activity, no membrane sta

Method used

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  • Compound antihypertensive drug composition
  • Compound antihypertensive drug composition
  • Compound antihypertensive drug composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1: Preparation of Compound Atenolol Amlodipine Double Layer Tablets (12.5mg / 2.5mg)

[0053] Tablet prescription:

[0054]

[0055] Coating prescription:

[0056]

[0057] Compound atenolol amlodipine bilayer tablet (12.5mg / 2.5mg) preparation process:

[0058] The first layer (atenolol layer) is granulated by wet granulation process:

[0059] Atenolol was pulverized through an 80-mesh sieve for subsequent use;

[0060] Use 50% ethanol as solvent, make povidone K-30 into 1.4-1.6% concentration of povidone K-30 solution, as adhesive, stand-by;

[0061] Mix the atenolol (12.5g) of the above prescription amount with microcrystalline cellulose (116.7g), calcium hydrogen phosphate (60g), half amount of sodium carboxymethyl starch (4.15g) in a wet granulator, add viscosity Compound granulation. After the prepared granules were ventilated and dried at 50°C, another half amount of sodium carboxymethyl starch (4.15 g) and magnesium stearate (1 g) were added and ...

Embodiment 2

[0067] Example 2: Preparation of Compound Atenolol Amlodipine Double Layer Tablets (12.5mg / 2.5mg)

[0068] Tablet prescription:

[0069]

[0070] Coating prescription:

[0071]

[0072] The above formula was prepared according to the preparation method of Example 1 to prepare 1000 bilayer preparations.

Embodiment 3

[0073] Example 3: Preparation of Compound Atenolol Amlodipine Double Layer Tablets (12.5mg / 2.5mg)

[0074] Tablet prescription:

[0075]

[0076] Coating prescription:

[0077]

[0078] The above formula was prepared according to the preparation method of Example 1 to prepare 1000 bilayer preparations.

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PUM

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Abstract

The invention belongs to the technical field of medicines, and relates to a compound antihypertensive drug composition. The composition is a compound bilayer tablet containing atenolol and amlodipine, wherein the first layer of tablet contains effective dosage (12.5mg) of atenolol; and the second layer of tablet contains effective dosage (2.5mg) of amlodipine. The preparation can be evenly and effectively dissolved, is good in stability, and has good clinical effect and low adverse effect rate.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a compound antihypertensive pharmaceutical composition, which is a compound double-layer tablet containing atenolol and amlodipine, and the preparation has good clinical effect and relatively low adverse reaction incidence. Background technique [0002] Hypertension is a common clinical disease, frequently-occurring disease, and an important risk factor for various cardiovascular diseases, which affects the physiological functions of the heart, kidney and other organs, eventually leading to their functional failure. For hypertensive groups of different races and ages, lowering their blood pressure can effectively reduce the occurrence of cardiovascular diseases. According to statistics, there are 160 million hypertensive patients in my country. In 2002, the awareness rate of hypertension in my country was 30.2%, the treatment rate was 24.7%, and the control rate was 6.1%. In 2000...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61K9/28A61K9/24A61K9/20A61P9/12A61K31/165
Inventor 吴涛黄晶晶潘阳邱彤雷丽郗砚彬刘雅娣营亚萍
Owner CHINA RESOURCES DOUBLE CRANE PHARMA COMPANY
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