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Blueberry leaf extract with protective effect on alcoholic liver damage

A technology for alcoholic liver damage and protection, applied in the field of blueberry leaf extract, can solve problems such as liver damage

Active Publication Date: 2013-07-24
NANJING ZIYU BLUEBERRY TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Alcohol will cause many negative effects on the body, inhibit the function of the nervous system, cause drowsiness, and cause irreversible damage to the liver function in the long run. Therefore, it is very important to develop an extract that has a protective effect on alcoholic liver damage. Necessary, broad application prospects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Example 1 Preparation of a blueberry leaf extract that has a protective effect on alcoholic liver damage

[0009] After crushing 100g of blueberry leaves, heat and boil with water as a solution, add 1000mL of water each time to extract three times, filter and combine the filtrate, concentrate the extract to 400mL, and first obtain the sample solution; the sample solution is added to D101 macroporous resin (100g) for chromatography The column uses deionized water (2L) and ethanol solutions of different concentrations (each concentration 2L) as eluents, and the flow rate is about 6mL / min; the solvent of the part solution obtained by elution of 50% ethanol solution is recovered, and the concentrated solution is frozen After drying, it is weighed and sealed for storage, which is the extract of the present invention.

Embodiment 2

[0010] Effect of Example 2 Extract on Mouse Alcoholic Liver Injury Model

[0011] Commercially available edible alcohol (concentration 52%) was used as the modeling drug, and the dosage was 0.1ml / 10g. After the administration, the mice would all enter a sleep state within 15 minutes, and the sleep time was about 2 to 2 hours. After one week of continuous administration, a certain tolerance began to appear, and the sleep time decreased (large individual differences). After four weeks of continuous administration, particles appeared on the surface of the liver. During anatomy, the liver was found to be white in color, foamy in texture, and easily broken.

[0012] Take the 50% ethanol extraction site as the active screening site, configure 10mg / ml CMC-Na suspension solution, and administer it 30 minutes before alcohol gavage. It is found that this site can significantly improve the alcohol tolerance of mice and start sleep time Obvious delay (the longest one just sleeps for nearl...

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PUM

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Abstract

The invention relates to a blueberry leaf extract with protective effect on alcoholic liver damage. The blueberry leaf extract is obtained by detocting blueberry leaves with water, enriching with macroporous resin and eluting with ethanol. The blueberry leaf extract respectively shows activity of resisting alcoholic liver damage in experiments in vitro.

Description

technical field [0001] The invention relates to a blueberry leaf extract which has a protective effect on alcoholic liver damage. Background technique [0002] Alcohol will cause many negative effects on the body, inhibit the function of the nervous system, cause drowsiness, and cause irreversible damage to the liver function in the long run. Therefore, it is very important to develop an extract that has a protective effect on alcoholic liver damage. Necessary, the application prospect is broad. Contents of the invention [0003] The invention provides a blueberry leaf extract which has a protective effect on alcoholic liver damage. [0004] The present invention is achieved through the following technical solutions: [0005] After the blueberry leaves are crushed, they are heated and boiled in water for three extractions. After filtration, the filtrates are combined and concentrated, and the active ingredients are enriched with macroporous resin. They are eluted with de...

Claims

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Application Information

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IPC IPC(8): A61K36/45A61P1/16A61K127/00
Inventor 於红贺善安王天寿张剑
Owner NANJING ZIYU BLUEBERRY TECH
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