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Novel sorbent for endotoxins

A technology of sorbent and endotoxin, applied in the direction of solid sorbent liquid separation, suction equipment, other chemical processes, etc., can solve the problems of complex production methods, high patient mortality, high production costs, etc., to reduce desorption and save time , the effect of speed improvement

Inactive Publication Date: 2013-07-24
FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Other disadvantages arise from expensive and complex production methods and the higher production costs associated therewith
[0016] Although the above-mentioned Toraymyxin adsorption module has been able to reduce the mortality rate of patients suffering from endotoxin poisoning (especially sepsis) through clinical administration, the mortality rate of patients suffering from severe sepsis and septic shock despite the use of the maximum amount of treatment still very high

Method used

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  • Novel sorbent for endotoxins

Examples

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example 1

[0055] 1. Example 1: Production of a sorbent (adsorbent) according to the invention

[0056] To produce the sorbent according to the invention, a neutral, hydrophobic polystyrene-divinylbenzene copolymer is firstly coated adsorptively with polymyxin B (PMB) and then with human serum albumin (HSA).

[0057] 1.1. Provide a water-insoluble porous support with a neutral, hydrophobic surface

[0058] Polystyrene-divinylbenzene copolymers of different particle sizes (hereinafter simply referred to as "polymer" or "support" or "uncoated adsorbent") were purchased from The Dow Chemical Company with an average pore size of 30 to 40nm. Table 1 lists the polystyrene-divinylbenzene copolymers.

[0059] Table 1: Polystyrene-divinylbenzene copolymers

[0060]

[0061] Vector #1824 was provided by the manufacturer as a suspension and washed 5 times in NaCl.

[0062] Vector HPR10 was pretreated according to the manufacturer's instructions.

[0063] 1.2. Adsorptive coating of polyme...

example 3

[0104] 3. Example 3: Adsorption of Heparin and Protein C

[0105] 3.1. Test background

[0106] A disadvantage of many adsorbents is that not only the substance to be removed, in this case endotoxin, but also a large number of physiologically important proteins and factors of the coagulation system (both anticoagulants and procoagulants) are eliminated. In this regard, special mention must be made of the patient's own coagulation inhibitors, such as protein C and protein S. Of particular importance is protein C as a coagulation inhibitor. Decreased concentrations of protein C in the body can lead to serious coagulation complications such as venous thrombosis and pulmonary embolism. The anticoagulant heparin, which is additionally introduced into the extracorporeal blood circuit by infusion, is eliminated by many adsorbents. This leads to an imbalance of the coagulation system in the body and an undesired anticoagulant effect in the extracorporeal and / or in vivo blood circ...

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Abstract

The invention relates to a sorbent for removing endotoxins from a biological liquid, comprising a water-insoluble, porous substrate having a neutral, hydrophobic surface, wherein the surface of the substrate has an adsorbent coating made of polymyxin and albumin, wherein polymyxin and albumin are bonded to the surface of the substrate in a noncovalent manner. The invention further relates to a method for producing such a sorbent. The sorbent is used in extracorporeal blood purification, in particular in order to treat individuals who have sepsis.

Description

technical field [0001] The present invention relates to polymyxin-coated sorbents for the removal of endotoxins from biological fluids. Background technique [0002] Endotoxins are lipopolysaccharides (LPS) in the cell walls of Gram-negative bacteria and are released by cell lysis. In fact, lipopolysaccharide is the most common lipid component in the outer cell membrane of Gram-negative bacteria. Endotoxins are pyrogenic substances, ie as they reach the body during intoxication, eg by microorganisms, the infected person exhibits a severe inflammatory reaction with fever, as well as systemic effects. The presence of endotoxins in the blood circuit leads to uncontrolled activation of immune cells and leads to an imbalance in the coagulation system. Depending on its concentration, it can lead to sepsis, symptoms of which include, among others, high fever, low blood pressure and, in severe cases, multiorgan failure. Sepsis is a disease to be taken very seriously; the mortalit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36B01D15/00B01J20/26B01J20/32
CPCA61M1/36B01J20/28078B01J20/267B01J20/3248A61M2001/3486B01J20/3285B01J20/3274B01J20/3251B01J20/321B01J20/3255B01J20/3253B01J20/28004A61M1/3472A61M1/3486
Inventor 迪特尔·法尔肯哈根史蒂芬·哈姆简·哈特曼维多利亚·韦伯
Owner FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
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