Novel sorbent for endotoxins

A technology of sorbent and endotoxin, applied in the direction of solid sorbent liquid separation, suction equipment, other chemical processes, etc., can solve the problems of complex production methods, high patient mortality, high production costs, etc., to reduce desorption and save time , the effect of speed improvement
CN103221079AInactive Publication Date: 2013-07-24FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
Publication Date
2013-07-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a sorbent for removing endotoxins from a biological liquid, comprising a water-insoluble, porous substrate having a neutral, hydrophobic surface, wherein the surface of the substrate has an adsorbent coating made of polymyxin and albumin, wherein polymyxin and albumin are bonded to the surface of the substrate in a noncovalent manner. The invention further relates to a method for producing such a sorbent. The sorbent is used in extracorporeal blood purification, in particular in order to treat individuals who have sepsis.
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Description

technical field

[0001] The present invention relates to polymyxin-coated sorbents for the removal of endotoxins from biological fluids. Background technique

[0002] Endotoxins are lipopolysaccharides (LPS) in the cell walls of Gram-negative bacteria and are released by cell lysis. In fact, lipopolysaccharide is the most common lipid component in the outer cell membrane of Gram-negative bacteria. Endotoxins are pyrogenic substances, ie as they reach the body during intoxication, eg by microorganisms, the infected person exhibits a severe inflammatory reaction with fever, as well as systemic effects. The presence of endotoxins in the blood circuit leads to uncontrolled activation of immune cells and leads to an imbalance in the coagulation system. Depending on its concentration, it can lead to sepsis, symptoms of which include, among others, high fever, low blood pressure and, in severe cases, multiorgan failure. Sepsis is a disease to be taken very seriously; the mortalit...

Claims

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