A kind of Periplaneta americana extract and its preparation method and application

A technology of Periplaneta americana and its extract, which is applied in the field of medicine, can solve problems such as inability to continue treatment, resistance, and delay in treatment, and achieve good clinical application value, no fishy smell, and stable and reliable quality

Active Publication Date: 2015-10-28
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some patients have resistance during use, and even experience nausea, vomiting and other gastrointestinal discomforts, resulting in inability to continue treatment and delaying the condition

Method used

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  • A kind of Periplaneta americana extract and its preparation method and application
  • A kind of Periplaneta americana extract and its preparation method and application
  • A kind of Periplaneta americana extract and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Weigh 40kg of fresh worms of Periplaneta americana, add acetone to heat and reflux 4 times, add 3 times the amount each time, reflux for 1 hour each time, wave off the acetone, add water to decoct and extract 3 times, add water 5 times the volume of the medicinal material each time , decocted and extracted for 1 hour each time, filtered; the filtrate was concentrated under reduced pressure at 70°C to a relative density of 1.08 (measured at 60°C), added ethanol until the alcohol content reached 75%, stood at 0°C for 12 hours, and filtered; the filtrate Recover ethanol under normal pressure until there is no alcohol smell, add water until each milliliter is equivalent to 1 gram of crude drug, and filter; the filtrate passes through a D101 macroporous adsorption resin column, rinses the resin column with pure water, and collects the effluent until the ninhydrin reaction in the effluent Negative; the effluent passes through the polyamide column, rinses the resin column w...

Embodiment 2

[0042] Weigh 30kg of dried Periplaneta americana, add acetone to heat and reflux 3 times, add 4 times the amount each time, reflux for 60 minutes each time, wave off the acetone, add water to decoct and extract 3 times, add water 10 times the volume of the medicinal material each time , decocted and extracted for 1 hour each time, filtered; the filtrate was concentrated under reduced pressure at 75°C to a relative density of 1.05 (measured at 60°C), added ethanol until the alcohol content reached 80%, stood at 4°C for 12 hours, and filtered; the filtrate Recover ethanol under reduced pressure until there is no alcohol smell, add water until each milliliter is equivalent to 1 gram of crude drug, and filter; the filtrate passes through HPD100 macroporous adsorption resin column, rinses the resin column with pure water, and collects the effluent until the ninhydrin reaction in the effluent Negative; the effluent passes through the polyamide column, rinses the resin column with...

Embodiment 3

[0044] Weigh 25kg of dried Periplaneta americana, add acetone, heat and reflux 3 times, add 3 times the amount each time, reflux for 30 minutes each time, wave off the acetone, add water to decoct and extract 2 times, add water 20 times the volume of the medicinal material each time , decocted and extracted for 2 hours each time, filtered; the filtrate was concentrated under reduced pressure at 68°C to a relative density of 1.25 (measured at 60°C), added ethanol until the alcohol content reached 55%, stood at 25°C for 24 hours, and filtered; the filtrate Recover ethanol under reduced pressure until there is no alcohol smell, add water until each milliliter is equivalent to 2 grams of crude drug, and centrifuge; the supernatant passes through the AB-8 macroporous adsorption resin column, rinses the resin column with pure water, and collects the effluent until the effluent is indene The triketone reaction was negative; the effluent passed through the polyamide column, and the...

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Abstract

Disclosed are a Periplaneta americana extract and the preparation method therefor. The method uses acetone for reflux and water for extraction. The resulting extract is concentrated, to which ethanol is added, then ethanol is recovered to obtain a filtrate. The filtrate is then processed through an adsorption resin column, and the effluent liquid is collected until the ninhydrin reaction is negative. The liquid is processed through a polyamide column, and the effluent liquid is collected until the ninhydrin reaction is negative. The effluent liquid is concentrated and dried. Also disclosed is the use of the Periplaneta americana extract in the manufacture of an inductive solution for orientedly inducing the differentiation from mesenchyme stem cells to epidermal cells.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of an extract of Periplaneta americana. Background technique [0002] Periplaneta americana (Periplaneta americana) is an insect belonging to the genus Periplaneta in the subclass Insecta Pterosae, Blatella order, Blattedae, commonly known as "cockroach". Taste: salty, cold; Cure: blood stasis syndrome with hard cold and heat, broken accumulation, closed throat, internal cold without seeds". "Cockroach" is its common name first seen in "Compendium of Materia Medica Supplements", and it is also called Shijiang and slippery insect; different places have its own name, such as: stealing oil woman, tea woman, stove ant, etc. Blattidae (Blattidae) is a huge insect family that has existed on the earth for 320 million years. It is a creature that appeared in the same era as dinosaurs. Undoubtedly, it is one of the most vigorous, oldest, and most successful insect ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A61P17/02C12N5/071A61K35/63
CPCA61K35/63A61P17/02
Inventor 耿福能马秀英吴桃清
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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