Novel pharmaceutical composition of 2-(2-fluoro-4-biphenyl)-propionic acid
A composition and drug technology, applied in the field of medicine, can solve the problems of adverse reactions, high cost of flurbiprofen axetil, aggravating the burden on patients and society, etc., and achieve a good effect of reconstitution
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Embodiment 1
[0047] Preparation of powder injection with arginine: flurbiprofen molar ratio of 0.6:1
[0048] prescription
[0049] Flurbiprofen 24.4g
[0050] Arginine 10.4g
[0051] The volume of water for injection is set to 2.44L
[0052] 1000 pieces in total
[0053] According to the powder injection workshop's requirements for material entry and exit, equipment and utensils and the use of standard operating procedures, both arginine and flurbiprofen are treated with activated carbon for injection. Add about 1.8 liters of water for injection to 10.4g of arginine, stir at room temperature until dissolved, then add 24.4g of flurbiprofen to the resulting arginine solution, mix at room temperature until dissolved, add water to the resulting solution to reach 2.44 Liter, get the molar ratio (arginine: flurbiprofen) as 0.6:1 The flurbiprofen solution of 10mg / ml, then fill the qualified drug solution in a sterile antibiotic glass bottle, and then place the glass bottle in a freeze dryer for 4 hour...
Embodiment 2-4
[0055] The same method as in Example 1 to prepare arginine: flurbiprofen molar ratio of 0.9:1, 1:1 and 1.5:1 freeze-dried powder.
Embodiment 5
[0057] Preparation of injection with molar ratio of arginine and flurbiprofen of 0.6:1
[0058] prescription
[0059] Flurbiprofen 24.4g
[0060] Arginine 10.4g
[0061] The volume of water for injection is set to 2.44L
[0062] 1000 pieces in total
[0063] Add 10.4 g of arginine and 24.4 g of flurbiprofen to 1.4 liters of water for injection, heat and stir until dissolved, and then dilute the volume to 2.44 liters with water for injection to obtain the molar ratio (arginine: flurbiprofen) )for 0.6:1 The 10mg / ml flurbiprofen solution is added to needle carbon at 0.15% of the total water, kept at 60℃ and stirred for 10-15 minutes, and then the resulting solution is filtered through a G6 sand rod and a 0.2 micron microporous filter membrane. , Dispense into the receiving bottle, fill and seal after passing the clearness inspection, and the products after the filling will be routinely terminally sterilized immediately. The sterilized products will be packaged after vacuum leak detecti...
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