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Application of polyflavanostilbene A in preparation of anti-human fungus medicine

A technology against human fungi and drugs, applied in the field of compounds, can solve problems such as digestive tract irritation and strong accumulation of toxicity

Inactive Publication Date: 2013-09-18
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots

Method used

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  • Application of polyflavanostilbene A in preparation of anti-human fungus medicine
  • Application of polyflavanostilbene A in preparation of anti-human fungus medicine
  • Application of polyflavanostilbene A in preparation of anti-human fungus medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of the compound Polyflavanostilbene A tablet involved in the present invention:

[0013] Take 20 grams of compound Polyflavanostilbene A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of the compound Polyflavanostilbene A capsules involved in the present invention:

[0015] Get 20 grams of compound Polyflavanostilbene A, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and pack into capsules to make 1000 capsules.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0017] Experimental example: Anti-fungal activity of Polyflavanostilbene A in humans

[0018] The anti-fungal activity experiment against human body adopts the method of concentration dilution, and each determination is repeated three times. The test pathogens include Trichomonas rubrum, Microsporum lanoides and Trichomonas clumps, and the concentration of bacteria solution is 105 / mL. The initial concentration of Polyflavanostilbene A is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), serially diluted to 0.098 μg / mL, the same volume of bacteria liquid and test samples are mixed and cultured in a 96-well plate, and the human fungus culture temperature 28°C respectively, observe after 24 hours of incubation time, if no colonies are found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the results of Polyflavanostilbene A against human fungi are shown in Table 1.

[0019] Table 1 Polyf...

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Abstract

The invention relates to an application of polyflavanostilbene A in the preparation of an anti-human fungus medicine, and belongs to the field of medicines. The polyflavanostilbene A has very strong effects on inhibiting trichophyton rubrum, microsporum lanosum or trichophyton tonsurans, and therefore the polyflavanostilbene A can be used as an anti-human fungus compound, and is hopefully to be applied to the preparation of relevant medicines. The invention discloses the application of the polyflavanostilbene A in the preparation of the anti-human fungus medicine for the first time; as the skeleton type is a brand-new skeleton type and the inhibition activity of the polyflavanostilbene A on human fungi is unexpectedly strong, the possibility of being inspired by other compounds is eliminated, and the polyflavanostilbene A has substantive distinguishing features; and the application of the polyflavanostilbene A in the prevention and treatment of human fungus infection is a significant progress.

Description

technical field [0001] The present invention relates to a new application of compound Polyflavanostilbene A, in particular to the application of Polyflavanostilbene A in the preparation of antifungal drugs for human body. Background technique [0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots. [0003] The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P31/10
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH
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