A non-rigid registration method for 3D CT images of mice

A non-rigid registration, CT image technology, applied in the field of medical image processing, can solve the problems of difficult to achieve manual segmentation of mouse atlas bones, long registration time, and complicated registration process, and achieve registration of three-dimensional images. Fast, reduced registration time, easy to achieve results

CN103337065BInactive Publication Date: 2016-03-02XIDIAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2016-03-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

A non-rigid registering method of a mouse three-dimensional CT image comprises the following steps: A, a direction and a position of a source image of a mouse three-dimensional CT image are calibrated; B, a threshold segmentation algorithm is used to segment the mouse image to obtain a mouse bone of the source image and a mouse bone of a target image, a center of mass of a bone slice connected domain is extracted to serve as a characteristic point, so that a source image characteristic point and a target image characteristic point are obtained; C, the source image characteristic point and the target image characteristic point in the step B are matched, the matched characteristic point is used to calculate a thin plate batten transformation matrix, and a hierarchical transformation mode is used to carry out the thin plate batten transformation to the mouse source image; and D, the mouse source image after the thin plate batten transformation and the target image carry out a fine registering. According to the invention, when the characteristic points are extracted, the number of characteristic points is reduced; the hierarchical transformation mode is used to overcome the defect of long registering time; an automatic registering in the image registering is basically realized; and registering the three-dimensional mouse image is easier.
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Description

technical field

[0001] The invention relates to the field of medical image processing, and further relates to a registration method of medical images. The invention can be used for registration of three-dimensional CT images of mice. Background technique

[0002] Medical image registration plays an important role in medical image analysis and clinical experiments, and can be used in image segmentation, image fusion, surgical navigation and other technologies. In medical experiments, mice are often used as research objects, and image registration is necessary before analyzing and processing 3D images of mice. However, the body structure of mice is relatively complex, and there are often irregular non-rigid deformations between different images, and the degree of deformation of soft tissues and bones is different. It is necessary to treat soft tissues and bones differently during registration, otherwise it cannot Good alignment results were obtained. The traditional rigid r...

Examples

Embodiment Construction

[0057] Combine below figure 1 The specific implementation steps of the present invention are further described in detail.

[0058] Step 1. Rigid calibration of the source image

[0059] During rigid calibration, first correct the direction of the head and tail of the mouse in the image, then correct the supine posture of the mouse, and finally align the central axis of the mouse.

[0060] Step 2. Extract feature points of source image and target image

[0061] (1) Select the threshold, and use the threshold segmentation method to extract the bone of the mouse in the source image and the target image to obtain the source bone image and the target bone image. In this embodiment, the threshold value is 105;

[0062] (2) Calculate the area of ​​each connected region in the target bone image perpendicular to the main axis of the mouse, calculate the centroid of the connected region with an area greater than 10, and obtain the feature points of the target image;

[0063] (3) Calc...