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Inhibitors of apoptosis and uses thereof

一种细胞、凋亡的技术，应用在细胞凋亡抑制剂领域，能够解决信号传导途径未完全被阐明等问题

Active Publication Date: 2013-11-20
CENT NAT DE LA RECH SCI (C N R S) +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the in vivo apoptotic signaling pathways involved during myocardial ischemia / reperfusion have not been fully elucidated

Method used

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  • Inhibitors of apoptosis and uses thereof
  • Inhibitors of apoptosis and uses thereof
  • Inhibitors of apoptosis and uses thereof

Examples

Experimental program
Comparison scheme
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Embodiment

[0174] The following examples describe some of the preferred modes of making and practicing the invention. It should be understood, however, that these examples are for illustrative purposes only and are not meant to limit the scope of the invention.

[0175] Synthesis of membrane-bound reversed-phase peptide arrays

[0176] Peptides were synthesized on N-modified CAPE-membranes (Bhargava et al., Mol. Recognit, 2002, 15:145) and prepared by a MultiPep SPOT-robot (INTAVIS Bioanalytical Instruments AG, Cologne, Germany). Array design was performed with the help of the built-in software LISA 1.71. The synthesis started with a point definition using a standard protocol [Frank, Tetrahedron, 1992, 48:9217], followed by a solution of Fmoc-cysteine-(Trt)-Opfp (0.3M) in N-methylpyrrolidone (NMP) and Fmoc - Coupling of alanine-Opfp (double coupling, 15 min reaction each). After Fmoc cleavage with piperidine in DMF (20%), 4-hydroxymethylphenoxyacetic acid (HMPA) dissolved in dimethylf...

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Abstract

The invention relates to fragments of the DAXX and FADD proteins that inhibit cell apoptosis, in particular cell apoptosis mediated by the Fas receptor. The invention also relates to derivatives of said anti-apoptotic fragments, conjugates comprising said fragments, pharmaceutical compositions comprising said fragments, and to the medical applications of said fragments, derivatives, conjugates, and pharmaceutical compositions thereof in the treatment or prevention of diseases and conditions associated with apoptosis.

Description

[0001] related application [0002] This patent application claims priority to International Patent Application No. PCT / IB2010 / 003158 filed November 18, 2010, which is incorporated herein by reference in its entirety. field of invention [0003] The present invention relates to inhibitors of apoptosis and their use, especially in medicine. Background of the invention [0004] Coronary heart disease is the leading cause of death worldwide, accounting for 3.8 million reported deaths in men and 3.4 million deaths in women each year. As the population ages and complications (e.g., obesity and metabolic syndrome) become more prevalent, as in recent years, the large public health burden caused by ischemic heart disease is likely to increase even further (in Yellon et al. , N Engl J Med, 2007;357:1121-1135). [0005] Coronary heart disease refers to the inability of the coronary circulation to provide sufficient blood supply to the heart muscle and surrounding tissues. The most ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/47A61K38/08
CPCA61K38/1709C07K14/4747A61K38/08A61K38/10A61K45/06A61K38/13C07K2319/10A61K2300/00A61P37/06A61P43/00A61P9/00A61P9/10A61K47/64C07K7/06A61K38/00
Inventor S·巴雷尔J·纳若特B·勒布勒P·布瓦格兰C·皮奥
Owner CENT NAT DE LA RECH SCI (C N R S)