Applications of lagochilus diacanthophyllus extract in preparing hemostasis anti-inflammatory medicament

A kind of technology of harelip flower and extract, applied in the field of medicine, can solve the problems such as inflammation and hemorrhage of harelip flower that have not been seen

Inactive Publication Date: 2013-11-27
上海中药标准化研究中心 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been reports of clinical medicinal use of this genus in the former Soviet Union and the United States. Although there are folk records of the medicinal use of some species of this genus in Xinjiang and other places in my country, there is no such thing as the preparation and treatment of inflammation and hemorrhagic diseases. related reports of drugs or health food

Method used

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  • Applications of lagochilus diacanthophyllus extract in preparing hemostasis anti-inflammatory medicament
  • Applications of lagochilus diacanthophyllus extract in preparing hemostasis anti-inflammatory medicament
  • Applications of lagochilus diacanthophyllus extract in preparing hemostasis anti-inflammatory medicament

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Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0030] 1. Experimental materials

[0031] 1.1 Medicinal materials

[0032] Lagochilus diacanthophyllus (Pall.) Benth] was collected from Xinjiang.

[0033] 2. Experimental method

[0034] 2.1 Preparation of sample solution

[0035] The preparation method of the water extract of the whole plant of Laminaria vulgaris: take the whole plant, dry it in the shade at room temperature and smash it through an 80-mesh sieve, take 200g of dry powder, add 10 times the amount of water, heat and decoct for a total of three times (4h, 4h, 3h), after filtering separately, the three filtrates are combined, concentrated, and dried in a water bath to obtain a water extract extract. The extract yield was 21.23%.

[0036] The preparation method of the 95% B extract of the whole plant of Laminaria lanceolata: Take the whole plant, dry it in the shade at room temperature and smash it through an 80-mesh sieve, take 200g of dry powder, add 10 times the amount of 95% ethanol, heat and reflux for extraction, a t...

specific Embodiment 2

[0037] 2.2 Determination of blood clotting time and bleeding time in mice:

[0038] Experimental animals: ICR mice weighing 20±2g (for the determination of clotting time and bleeding time), SD rats weighing about 300g (for the determination of platelet aggregation function), rats weighing 250-270g (for blood Determination of agglutination parameters), rats weighing 90-110 g (for the determination of carrageenan-induced toe swelling), provided by the Animal Experiment Center of Shanghai University of Traditional Chinese Medicine. Place in a regular breeding environment, free to eat and drink.

[0039] 45 minutes after the last administration, insert a capillary into the mouse's intraocular canthus to take blood. When the blood fills the capillary, start timing and place the capillary flat on the table. Every 20s or so, alternately break the capillary from both edges. Check for the presence of clotting filaments on a small section of the blood vessel. Once clotting filaments appear,...

specific Embodiment 3

[0072] A preparation method of the tablet of the whole plant water extract of Lagolia serrata, according to the following sequence:

[0073]

[0074]

[0075] The specific method is: mix the water extract of the whole plant of Laminaria lobata, lactose, hydroxypropyl cellulose, wheat starch, and polyoxyethylene stearate for 20 minutes, add 95% ethanol, and add orange essence, Vitamin C, magnesium stearate, mix for 10 minutes. Tablet.

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Abstract

The invention model discloses applications of a whole-plant lagochilus diacanthophyllus extract. The applications lie in that as active ingredients, the whole-plant lagochilus diacanthophyllus water extract and 95% ethanol extract are used for preparing medicaments or health-care food for treating acute inflammation and hemorrhage. The applications of the lagochilus diacanthophyllus extract have important significance in research and applications of civil national medicinal lagochilus plant.

Description

Technical field [0001] The present invention relates to the hemostatic and anti-inflammatory effects of the whole herb extract of Laminaria lanceolata, in particular, it effectively reduces bleeding and inhibits the development of inflammation, and belongs to the technical field of medicine. Background technique [0002] In the physiological function of blood, there are two opposite and unified processes of fibrin stroke and dissolution to ensure normal blood flow. Under the influence of factors such as trauma or certain diseases, bleeding occurs when the balance is disrupted. Hemostasis mainly involves three important factors: blood coagulation, platelet aggregation and vasoconstriction. Inflammation is a complex defensive response of a living body with a vascular system to injury factors. These responses include changes in blood vessels, cells, interstitium, nerves and body fluids. The inflammatory process involves the participation of a variety of cells and factors, of which ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A23L1/29A61K9/20A61P29/00A61P7/04A23L33/00
Inventor 徐红焦莹张成刚侴桂新
Owner 上海中药标准化研究中心
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