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Preparation method for glucomannan acid hydrolyzed product

A technology of glucomannan and hydrolyzate, which is applied in the field of glucomannan acid hydrolyzate and its preparation, to achieve the effects of controllable molecular weight, easy operation and good uniformity

Active Publication Date: 2011-11-16
PENGLAI NUOKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention is aimed at the preparation process of the existing glucomannan acid hydrolyzate and the corresponding monitoring method of the hydrolyzate.

Method used

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  • Preparation method for glucomannan acid hydrolyzed product
  • Preparation method for glucomannan acid hydrolyzed product
  • Preparation method for glucomannan acid hydrolyzed product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Preparation of the acid hydrolyzate of Baiji polysaccharide described in this example:

[0052] Weigh 10.0 g of Baiji polysaccharide (BT01) into a 2000 mL beaker, add 900 mL of distilled water, and heat to dissolve on a 60°C water bath. Set the temperature of the water bath to 75°C. After equilibrium, add 5mL of 1M HCl solution according to 0.5% (v / v) of the final volume of the solution to make up water so that the acid concentration is 0.005M and the final polysaccharide concentration in the solution is 1%. Timed, reacted for 3h 23min, took it out, cooled it in cold water immediately, quickly added 1M NaOH solution dropwise to neutralize to pH 6-7, and obtained the hydrolyzate. Add absolute ethanol (or 95% ethanol) to the hydrolyzed solution until the alcohol concentration is 60%, precipitate the hydrolyzed product, and dry to prepare Baiji polysaccharide BT02.

Embodiment 2

[0054] Preparation of the acid hydrolyzate of Baiji polysaccharide described in this example:

[0055] Weigh 10.0 g of Baiji polysaccharide (BT01) into a 1000 mL beaker, add 400 mL of distilled water, and heat to dissolve on a 60°C water bath. Set the temperature of the water bath to 85°C. After equilibrium, add 8 mL of 1M HCl solution according to 0.8% (v / v) of the final volume of the solution to make up water so that the acid concentration is 0.008M and the final polysaccharide concentration in the solution is 2%. Timed, reacted for 2.5 hours, and the subsequent treatment was the same as in Example 1 to prepare Baiji polysaccharide BT05.

Embodiment 3

[0057] Preparation of the acid hydrolyzate of Baiji polysaccharide described in this example:

[0058] Weigh 10.0 g of Baiji polysaccharide (BT01) into a 1000 mL beaker, add 400 mL of distilled water, and heat to dissolve on a 60°C water bath. Set the temperature of the water bath to 95°C. After equilibrium, add 8 mL of 1M HCl solution according to 0.8% (v / v) of the final volume of the solution to make up water so that the acid concentration is 0.008M and the final polysaccharide concentration in the solution is 2%. Timed, reacted for 3.5 hours, and the subsequent treatment was the same as in Example 1 to prepare Baiji polysaccharide BT07.

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Abstract

The invention relates to a preparation method for a glucomannan acid hydrolyzed product. The method is characterized by: adopting a material of uniform glucomannan having a weight average molecular weight less than 100 kDa; carrying out hydrolyzing for 0.5-10 hours in an acidity range of pH 1.0-pH 3.0 and in a temperature range of 45-100 DEG C to obtain the glucomannan acid hydrolyzed product having special weight average molecular weight. The invention further discloses a method for monitoring a reaction process by adopting pre-detected relative viscosity of the hydrolyzed product, and medical applications of the glucomannan acid hydrolyzed product in digestive tract ulcer and digestive tract bleeding. According to the present invention, the glucomannan acid hydrolyzed product with controllable weight average molecular weight and good uniformity can be obtained through the preparation method provided by the present invention; the preparation method has advantages of simple operation,easy control, suitability of industrial production and the like, and is applicable for preparing the natural-source glucomannan (such as bletilla striata, konjac gel and the like) hydrolyzed products.

Description

technical field [0001] The invention relates to a glucomannan acid hydrolyzate and its preparation technology, and in particular provides a glucomannan hydrolyzate with controllable molecular weight and good uniformity and a preparation method thereof. Background technique [0002] Polysaccharides are a class of special biopolymers composed of monosaccharide units with rich structural diversity. In organisms, polysaccharides exist as energy-storing macromolecules, or form tissue structure macromolecules through different supramolecular interactions; in addition, As a key substance in some biotransformation recognition (such as activity and selectivity) processes, polysaccharides have been increasingly recognized. Many organisms such as plants, animals, fungi, marine organisms and microorganisms can synthesize polysaccharides in large quantities through biological pathways. Polysaccharides from natural sources have good biocompatibility and degradability. Through chemical mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/02A61K31/736A61P1/04A61P7/04
Inventor 薛百忠刘江云张燕殷殷蔡培烈刘艳丽杨世林
Owner PENGLAI NUOKANG PHARMA CO LTD
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