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Application of Phyllanthoid A in preparing medicament for resisting human fungus

A technology against human fungi and drugs, applied in antifungal agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as irritation, dizziness, allergies, and strong accumulation of toxicity, and achieve outstanding substantive features and inhibit Active effect

Inactive Publication Date: 2013-12-25
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although the antibacterial agents currently used clinically have good curative effect on skin and superficial infection, but these antibacterial agents have strong cumulative toxicity, which often cause liver and kidney damage, digestive tract irritation, dizziness, allergies, etc. New antibacterial drugs with unique mechanisms have become one of the hot spots in drug research and development today

Method used

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  • Application of Phyllanthoid A in preparing medicament for resisting human fungus
  • Application of Phyllanthoid A in preparing medicament for resisting human fungus
  • Application of Phyllanthoid A in preparing medicament for resisting human fungus

Examples

Experimental program
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Effect test

Embodiment 1

[0011] Embodiment 1: the preparation of the compound Phyllanthoid A tablet involved in the present invention:

[0012] Take 5 grams of compound Phyllanthoid A, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional tableting.

Embodiment 2

[0013] Embodiment 2: the preparation of compound Phyllanthoid A capsules involved in the present invention:

[0014] Take 5 grams of compound Phyllanthoid A, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.

[0015] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0016] Experimental example 1: Phyllanthoid A anti-human fungal activity

[0017] The anti-fungal activity experiment against human body adopts the method of concentration dilution, and each determination is repeated three times. The test pathogens include Trichomonas rubrum, Microsporum lanoides and Trichomonas clumps, and the concentration of bacteria solution is 105 / mL. The initial concentration of Phyllanthoid A is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), serially diluted to 0.098 μg / mL, and the same volume of bacteria liquid and test samples are mixed and cultured in a 96-well plate, and the human fungus culture temperature 28°C respectively, observe after 24 hours of incubation time, if no colonies are found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the results of Phyllanthoid A against human fungi are shown in Table 1.

[0018] Table 1 Phyllanthoid A anti-human f...

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Abstract

The invention relates to application of Phyllanthoid A in preparing a medicament for resisting human fungus, and belongs to the field of medicines. Phyllanthoid A has a strong effect in inhibiting trichophyton rubrum, microsporum lanosum or trichophyton tonsurans, thus can be used as a human fungus resistance compound, is expected to be applied to related medicaments, and is disclosed for the first time. The frame model belongs to a brand-new frame model, and Phyllanthoid A has a strong activity in inhibiting human body fungus, has a highlighted substantial characteristic, and is remarkably progressed in preventing and treating human fungus infection.

Description

technical field [0001] The present invention relates to a new application of compound Phyllanthoid A, in particular to the application of Phyllanthoid A in the preparation of antifungal drugs for human body. Background technique [0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although the antibacterial agents currently used clinically have good curative effect on skin and superficial infection, but these antibacterial agents have strong cumulative toxicity and often cause liver and kidney damage, digestive tract irritation, dizziness, allergies, etc. New antibacterial drugs with unique mechanisms have become one of the hot spots in drug development today. [0003] The compound Phyllanthoid A involved in the present...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61P31/10
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH
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