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Chimeric antigen receptor combining EGFR (epidermal growth factor receptor) family proteins and composition and uses thereof

A chimeric antigen receptor and family technology, applied in the fields of molecular biology and immunology, can solve the problems of decreased therapeutic efficacy and avoid safety problems.

Active Publication Date: 2014-01-01
SHANGHAI CELL THERAPY GRP CO LTD
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  • Abstract
  • Description
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Problems solved by technology

However, CAR + The "cascade" effect caused by off-target T cells is very fast, and these suicide systems may not be able to function in time
Another approach is to reduce CAR + The number of T cells reinfused, but this program will reduce the efficacy of treatment

Method used

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  • Chimeric antigen receptor combining EGFR (epidermal growth factor receptor) family proteins and composition and uses thereof
  • Chimeric antigen receptor combining EGFR (epidermal growth factor receptor) family proteins and composition and uses thereof
  • Chimeric antigen receptor combining EGFR (epidermal growth factor receptor) family proteins and composition and uses thereof

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Embodiment Construction

[0041] As stated above, the present invention relates to a chimeric antigen receptor. More specifically, the chimeric antigen receptor transmits T cell activation-related signals through polypeptides capable of binding to EGFR membrane receptor family proteins widely expressed by tumor cells.

[0042] In the present invention, the term "chimeric antigen receptors" (chimeric antigen receptors, CAR) is an artificially modified receptor that can anchor specific molecules (such as antibodies) that recognize tumor antigens to immune cells (such as T cells), enabling Immune cells recognize tumor antigens and kill tumor cells.

[0043] The term "T cell activation-related signal" in the present invention refers to the two signals required for T cell activation, that is, the combination of TCR-CD3 complex on the surface of T cells and antigen peptide-MHC molecules provides the first signal for T cell activation, which determines Killing specificity of T cells; co-stimulatory molecules...

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Abstract

The present invention belongs to the fields of molecular biology and immunology and relates to a chimeric antigen receptor combining EGFR (epidermal growth factor receptor) family proteins and a composition and uses thereof The present invention particularly relates to the chimeric antigen receptor comprising polypeptides efficiently combining the EGFR family proteins and transmembrane domains, wherein the polypeptides efficiently combining EGFR family proteins comprise HERIN. The chimeric antigen receptor can promote the proliferation ability and killing effect of T cell at the premise of maintaining the killing specificity of the T cell.

Description

technical field [0001] The invention belongs to the fields of molecular biology and immunology, and relates to a chimeric antigen receptor combined with EGFR family proteins, its composition and application. Background technique [0002] Adoptive cell therapy (ACT) is a method to reinfuse processed autologous or allogeneic immune cells (mainly autologous cells) to tumor patients to enhance the patient's immune function and achieve therapeutic purposes. Currently, tumor ACT is progressing rapidly, and adoptive immunotherapy using tumor-infiltrating lymphocytes (TIL) has achieved very good clinical effects on melanoma (Science2002;298:850-4). However, T cell activation requires the stimulation of two signals, two T cell activation related signals. Among them, the TCR-CD3 complex on the surface of T cells binds to the antigen peptide-MHC molecule, providing the first signal for T cell activation and determining the killing specificity of T cells; co-stimulatory molecules (such...

Claims

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Application Information

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IPC IPC(8): C07K19/00C12N15/11C12N15/63C12N5/10A61K38/16A61K48/00A61P35/00A61P31/12
Inventor 钱其军金华君丁娜俞德超李林芳吴孟超
Owner SHANGHAI CELL THERAPY GRP CO LTD
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