Artificial cell membrane materials applied to photoinduction stem grafting and synthesis method thereof

A synthesis method and cell membrane technology, applied in the field of artificial cell materials and their synthesis, can solve the problems of poor universality, unfavorable long-term use, and low bonding strength of coatings, and achieve good biocompatibility, improved surface properties, and good medical use foreground effect
CN103483480AInactive Publication Date: 2014-01-01西安维萃禾生物科技有限公司 +1
4 Cites 11 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
西安维萃禾生物科技有限公司
Publication Date
2014-01-01
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses artificial cell membrane materials applied to photoinduction stem grafting and a synthesis method of the artificial cell membrane materials. The synthesis method of the artificial cell membrane materials comprises the following steps that 2-(dodecyl trithiocarbonate)-2- methyl propionic acid, dicyclohexyl carbodiimide, 4- dimethylamino pyridine and dichloromethane are added into a flask, all the components are stirred and dissolved under the protection of nitrogen, azide ethanol is dropwise added and stirred, washing is carried out through diluted hydrochloric acid and distilled water, solvents are removed through a reduced pressure distillation method, and a yellow oily liquid a is obtained; MPC, a midbody a, azo different nitrile and absolute ethyl alcohol are added into a boiling tube and are evenly dissolved, then after the nitrogen is removed through three times of 'vacuumizing-induction of highly pure nitorgen' operations on the boiling tube, and reaction away from light is carried out on the boiling tube in a sealed mode under the protection of highly pure nitrogen; the reaction liquid is precipitated through trichloromethane / diethyl ether mixed solvents, and solid products are collected. By means of the technical scheme, the artificial cell membrane materials have good biocompatibility, achieve the various effects of restraining of protein adsorption, anticoagulation, surface lubrication and the like, and have good medical prospects.
Need to check novelty before this filing date? Find Prior Art

Description

Technical field

[0001] The invention relates to an artificial cell material and a synthesis method thereof, in particular to an artificial cell membrane material that can be applied to light-induced grafting and a synthesis method thereof. Background technique

[0002] 2-Methylacryloyloxyethyl phosphorylcholine (MPC) polymer is a new biomimetic medical material. Because it can form a thin film with a cell membrane structure on the surface of the material, it is also called an artificial cell membrane. This material can exert good water affinity, inhibit protein adsorption and cell adhesion, surface lubrication and other effects, and has good biocompatibility. These characteristics make it useful in the biomedical field such as artificial heart, artificial blood vessel and vascular stent , Biochips and other aspects have good application potential.

[0003] At present, there are three main methods for preparing artificial cell membrane coatings on the surface of medical materials: ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More