MicroRNA biological markers for early lung cancer diagnosis and application thereof

A biomarker, early diagnosis technology, applied in recombinant DNA technology, DNA/RNA fragment, microbial determination/examination, etc., can solve the problems of low sensitivity and specificity, patient exposure, etc., and achieve the effect of high diagnostic value
CN103484550AActive Publication Date: 2014-01-01SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
Publication Date
2014-01-01

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Abstract

The invention relates to the field of biological detection, particularly to a group of microRNA biological markers for early lung cancer diagnosis and an application thereof. The microRNA biological marker comprises hsa-miR-125a-5p, hsa-miR-193a-5p, hsa-miR-25, hsa-miR-126 and hsa-miR-34a. The serum miRNA biological markers comprising the 5 miRNAs can not only be particularly applied to early lung cancer detection, but also be applied to advanced lung cancer detection.
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Description

technical field

[0001] The invention relates to the field of biological detection, in particular to a group of microRNA biomarkers for early diagnosis of lung cancer and applications thereof. Background technique

[0002] Lung cancer is the leading cause of cancer mortality worldwide, and its 5-year survival rate has improved only marginally over the past 3 years. Before reaching the advanced stage, lung cancer has no obvious clinical symptoms. More than 75% of lung cancer patients are diagnosed with locally advanced or metastatic lung cancer, and the late diagnosis of three quarters of lung cancer patients is the main reason for the low survival rate. The 5-year survival rate of patients with early-stage non-small cell lung cancer (NSCLC) is approximately 50%-70%, compared with 5%-15% and less than 2% for patients with stage III and stage IV NSCLC, respectively. Early diagnosis of lung cancer patients can effectively reduce their mortality. Chest x-rays and sputum cytolo...

Claims

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