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Preparation method and application of gastralgia tablets

A technology for Anwei Tablets and Corydalis Corydalis, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, antineoplastic drugs, etc., can solve the problems of large dosage for patients, rough process, and many impurities, and achieve the effect of reducing dosage

Inactive Publication Date: 2014-01-15
SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Anwei Tablets. However, the method of powdering is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the quality of this product. clinical application

Method used

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  • Preparation method and application of gastralgia tablets

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Effect test

Embodiment 1

[0016] Get Corydalis (vinegar system) 63g, alum (calcined) 250g, sea octopus (shell) 187g, join CO in the supercritical extractor, ethanol is as entrainer, and entrainer accounts for the volume percentage of total extraction solvent to be 4%, The extraction pressure is 15MPa, the temperature is 30°C, the CO2 flow rate is 1m1 / g crude drug min, and the extraction time is 150min to obtain a supercritical extract, add starch, 70% ethanol to make granules, dry, and press into tablets to make 500 tablets, each weighing 0.5 g.

Embodiment 2

[0018] Take Corydalis (made from vinegar) 63g, alum (calcined) 250g, sea octopus (shelled) 187g, add to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 3

[0020] Take Corydalis (made from vinegar) 63g, alum (calcined) 250g, sea octopus (shelled) 187g, add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

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Abstract

The invention provides a preparation method of gastralgia tablets. The gastralgia tablets are prepared by using 63 g of vinegar-processed rhizoma corydalis, 250 g of calcined alum and 187 g of shelled cuttlebone as raw material medicines and adopting supercritical extraction, so that the content of active ingredients is increased and the dosage is reduced. The invention further provides application of the gastralgia tablets to preparation of a medicament for inhibiting cell proliferation of human melanoma cells M14.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Anwei Tablets. Background technique [0002] Anwei Tablets are recorded in the Pharmacopoeia, the prescription is Corydalis Corydalis (made from vinegar) 63g, Alum (calcined) 250g, sea octopus (shelled) 187g, the above three ingredients, crushed into fine powder, sieved, mixed, add honey 125g and appropriate amount water, made into granules, dried, and compressed into 1000 tablets, which can promote qi and blood circulation, control acid and relieve pain. Used for epigastric tingling, acid regurgitation and belching caused by qi stagnation and blood stasis, gastric and duodenal ulcers, and chronic gastritis with the above syndromes. [0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Anwei Tablets. However, the method of powdering is rou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61K9/20A61P35/00
Inventor 不公告发明人
Owner SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT