Portable electrospray ion source device and mass spectrometer

Abstract

The invention discloses a portable electrospray ion source device. The portable electrospray ion source device comprises an electrospray module, a direct-current power source and a sheath gas supply module, wherein the electrospray module comprises a liquid storage block, a hollow capillary and a cavity, one end of the hollow capillary is connected to the bottom of a liquid storage tank of the liquid storage block to serve as a sample introduction end, the other end of the hollow capillary extends into the cavity to serve as a spray end, the sheath gas supply module is communicated with the cavity, sheath gas which is input and plays a role in atomization assistance acts on the spray end of the hollow capillary, and the direct-current power source acts on a sample solution in the hollow capillary to provide a high voltage needed by electrospray. A mass spectrometer comprises the portable electrospray ion source device. The portable electrospray ion source device and the mass spectrometer with the portable electrospray ion source device are small in size, convenient to carry, stable in spray and high in ionization efficiency.

Description

technical field [0001] The invention relates to the field of analytical instruments, in particular to a portable electrospray ion source device and a mass spectrometer with the device. Background technique [0002] The ion source is an integral part of the mass spectrometer, and its main function is to ionize the sample so that it can be introduced into the mass spectrometer for analysis. The ionization performance of the ion source determines the analytical performance and application fields of the mass spectrometer to a certain extent. Electrospray ionization (Electrospray Ionization, ESI) is one of the most commonly used ionization methods in mass spectrometry. It is a soft ionization technique that can be used to ionize most polar compounds, and it is easy to form multiply charged ions for macromolecular compounds. [0003] The process of electrospray can be simply described as: the liquid sample flowing through the end of the capillary is polarized under the action of ...

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Problems solved by technology

[0005] At present, the sampling device of the electrospray ion source generally uses a syringe and a micro-fluid syringe pump to drive the solution to flow in the pipeline to achieve sample injection, and uses a nitrogen bottle and a matching gas circuit to assist gas atomization, and its high-pressure module, The power module is large, resulting in a large volume of the entire device, which is not easy to move and carry. This device is only suitable for laboratory operations, not for on-site real-time detection and analysis, which greatly limits its use in small instruments, especially portable mass spectrometers. application in

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