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A vacuum electrospray ion source and mass spectrometer

An electrospray ion source and mass spectrometer technology, applied in the field of analytical instruments, can solve the problems of restricting the signal strength and detection limit of detection substances, ion transmission loss, etc., to achieve real-time online detection and analysis of samples, improve signal strength and detection limit, The effect of enhancing the desolvation effect

Active Publication Date: 2018-12-21
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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Problems solved by technology

[0004] The traditional electrospray ion source generates gas-phase ions in the atmospheric pressure environment, and then transports them to the vacuum cavity through the sample injection device and then is detected by the mass analyzer. This process will cause ion transmission loss, which restricts the signal strength and detection of the detected substances limit

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  • A vacuum electrospray ion source and mass spectrometer
  • A vacuum electrospray ion source and mass spectrometer

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Embodiment Construction

[0028] The present invention will be described in further detail below in combination with specific embodiments and with reference to the accompanying drawings.

[0029] The idea of ​​the present invention is: to generate ionization in the atmospheric environment, it is necessary to input ions into the vacuum cavity of the mass spectrometer by means of a sampling device, resulting in ion loss, and the liquid sample will crystallize at the tip of the capillary directly in the vacuum environment, making it impossible to generate ionization. spray. In some schemes, auxiliary devices such as laser heating and constant pressure injection are used to generate electrospray in a vacuum environment, but these auxiliary devices are bulky and complex in structure, which is not conducive to integration and is not suitable for portable mass spectrometers. In the present invention, through the improvement of the structure of the ion source, the liquid sample to be tested is sucked into the ...

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Abstract

Disclosed are a vacuum electrospray ion source and a mass spectrometer, the vacuum electrospray ion source comprising a hollow capillary (1), a vacuum cavity (4), a gas inlet pipe, a gas-supply device and an adjustment device. A first end of the hollow capillary is a sampling port (8), a second end thereof is a nozzle (9) for vacuum electrospray and extends into the vacuum cavity, and the gas pressure in the vacuum cavity is in the range of 10-4 - 200 Pa. One end of the gas inlet pipe extends into the vacuum cavity, and the other end thereof is connected to the gas-supply device. The adjustment device is used for adjusting gas to intermittently flow through the gas inlet pipe. The ion source enables electrospray ionization in the vacuum environment. The vacuum cavity of the vacuum electrospray ion source is in communication with the vacuum cavity of the mass spectrometer to form the mass spectrometer, such that loss during the ion transmission process can be reduced, and the signal intensity and the limit of detection when detection is performed can be improved.

Description

【Technical field】 [0001] The invention relates to the field of analytical instruments, in particular to a vacuum electrospray ion source and a mass spectrometer. 【Background technique】 [0002] Mass spectrometry has the characteristics of high sensitivity, high accuracy, fast analysis speed and strong qualitative ability, and is one of the most widely used analytical techniques. In order to meet the urgent needs of on-site real-time analysis and online rapid detection and analysis, miniaturization and portability have become an important direction for the development of mass spectrometers. [0003] The traditional electrospray ion source has a simple structure, and its working process can be simply described as: the sample solution passes through the capillary at a low flow rate. A high voltage is applied to the capillary, and the positive or negative of the voltage depends on the nature of the analyte. The voltage provides the electric field gradient required for charge s...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/16H01J49/26
CPCH01J49/167H01J49/26
Inventor 余泉张乾王晓浩钱翔倪凯
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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