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Rapid titration analysis method for N-methylglycine and salts thereof

A technology for quantitative analysis of methylglycine, which is applied in the field of rapid titration analysis of N-methylglycine (SA) and its salts, can solve problems such as long analysis time, large fluctuations in measurement data, and large errors in titration end point judgment, and achieve Positive guiding significance, strong practicability, and easy operation

Inactive Publication Date: 2014-02-12
CHINA NAT OFFSHORE OIL CORP +2
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  • Application Information

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Problems solved by technology

However, in these determination methods, the traditional acid-base titration method has a large error in judging the titration end point, large fluctuations in measurement data, and poor repeatability.
The GC method requires derivatization of amino acids before separation, and sample pretreatment is cumbersome and time-consuming; HPLC is the most widely used in amino acid analysis, but the disadvantages are large solvent consumption, long analysis time, and expensive chromatographic columns; CE is sensitive and reproducible in determination Insufficient performance; thin-layer chromatography method is time-consuming and time-consuming, which is not conducive to rapid and accurate analysis

Method used

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  • Rapid titration analysis method for N-methylglycine and salts thereof
  • Rapid titration analysis method for N-methylglycine and salts thereof
  • Rapid titration analysis method for N-methylglycine and salts thereof

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Embodiment

[0026] (1) Instruments and reagents

[0027] Instruments: Mettler pH meter, electromagnetic stirrer, composite glass electrode, burette

[0028] Reagents: standard NaOH solution 0.1mol / L, conventionally prepared, calibrated with oxalic acid; standard HCl solution; analytically pure grade isopropanol; analytically pure grade carbon disulfide.

[0029] N-methylglycine (SA) standard solution 10mg / L

[0030] (2) Sample titration method

[0031] Weigh 2.0g of SA sample into a 500mL Erlenmeyer flask, add 10mL of deionized water, adjust the pH to below 2.0 with 0.5mol / L standard HCl solution, add 40mL of isopropanol, titrate with 0.1mol / L NaOH standard solution, and record The change data of pH with the volume of titrant added during the titration process.

[0032] (3) Titration results of standard SA test solution

[0033] figure 1 It is a diagram of the titration result containing the SA standard solution, wherein the curve a is the titration curve of the change of the solutio...

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Abstract

The invention discloses a rapid titration analysis method for N-methylglycine and salts thereof, relates to a rapid titration analysis method for free acids, carboxylic acids and amino acids in an aqueous solution, and belongs to the field of quantitative analysis. Volumes corresponding to first-order derivative peak values of a titration curve are determined as titration end points. The method comprises the following steps of adjusting a pH value of a solution to be less than 2 by using strong acids during titration, performing titration by using a standard alkali solution, generating a first peak value indicating that free strong acids are titrated when the pH value is 6 to 7, generating a second peak value indicating that the carboxylic acids are titrated when the pH value is 10.5 to 11.5, adding carbon disulfide to realize the DTF (dithio-formylation) reaction of a secondary amine group in the N-methylglycine, continuing performing titration by using the standard alkali solution to generate a third peak value until the pH value is 9.5 to 10.5, and calculating the free acid content, carboxylic acid content and amino acid content of the solution respectively. The method can be conveniently and quickly operated, and is low in analysis cost, and a reliable result can be obtained.

Description

technical field [0001] The invention belongs to the technical field of chemical analysis and relates to a quantitative analysis method, in particular to a rapid titration analysis method for N-methylglycine (SA) and its salt. Background technique [0002] N-methylglycine can be used to produce N-acyl sarcosine, used as an active agent in high-grade skin care cream, toothpaste and shampoo, as well as high-grade medicinal soap and cosmetics. This product is also used as a dyeing aid for fast dyes agent, synthetic lubricating oil and antirust agent, fiber dyeing agent, antistatic agent, softening agent and biochemical reagent, etc. [0003] In the production of N-methylglycine and its derivatives, the accurate and rapid quantitative analysis of N-methylglycine has not been solved due to the influence of many factors in the synthesis process. In production, only the crystallization method can be used to roughly calculate its Yield and product content, causing more waste and inc...

Claims

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Application Information

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IPC IPC(8): G01N27/26
Inventor 秦立娟陶蕾武建刚王震王超陈军
Owner CHINA NAT OFFSHORE OIL CORP
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