Plant glucomannan silicone dressing as well as preparation method and application thereof

A technology of glucomannan silicone and glucomannan, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems of inconvenient life for patients, affect the appearance, irregular shape, etc., and achieve the purpose of inhibiting the formation of scars and congestion Improvement of condition and reduction of scar hyperplasia

Inactive Publication Date: 2014-02-19
合肥博太医药生物技术发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Scar tissue is a hyperplastic tissue produced during the repair of skin trauma. The scar is higher than the skin, irregular in shape, flushed and congested, hard on the surface, often with pigmentation, and accompanied by pain and itching, which brings inconvenience to the patient's life and affects the appearance. psychological and physical burden on patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Extraction and purification of plant glucomannan:

[0026] Take commercially available bletilla striata or konjac tubers, crush them thoroughly, boil in water for 3 hours, boil 8-10 times, filter with three layers of gauze, add twice the volume of absolute ethanol to the filtrate, mix well, and settle overnight at low temperature; centrifuge to remove the supernatant , take the precipitate and filter it, dissolve it in purified water, and use the Sevag method to remove the precipitated protein impurities [Staub et al., "Carbohydr Chem", Vol. Protein-free; extract with anhydrous ether to remove organic impurities, take the water phase and freeze-dry to obtain plant glucomannan, and store it at low temperature for later use.

Embodiment 2

[0028] The formula of plant glucomannan silicone dressing aerosol is as follows:

[0029] Vegetable Glucomannan 0.05%

[0030] Methicone 25%

[0031] Flusilazole 2.5%

[0032] Substrate margin

[0033] The plant glucomannan is the freeze-dried product obtained in Example 1; the dressing dosage form is an aerosol, and its matrix is ​​composed of ether (or petroleum ether) and Freon; the mass percentage of ether in the matrix component is 30 -35%, the mass percentage of Freon is 65%-70%.

[0034] During preparation, the plant glucomannan, methyl silicone oil and organic silicon antibacterial agent flusilazole are mixed, dissolved in ether or petroleum ether solvent, filled in an aluminum can, then injected with freon, irradiated and sterilized to make a finished product. To use, spray the finished product on the surface of the scar.

Embodiment 3

[0036] The formula of plant glucomannan silicone dressing gel is as follows:

[0037] Vegetable Glucomannan 1%

[0038] Methylphenyl silicone oil 50%

[0039] Flusilazole 0.1%

[0040] Substrate margin

[0041] The dosage form of the dressing is a gel, and its matrix component is a mixture of 2-3 components in polyvinyl alcohol, hydroxyethyl cellulose and hydroxymethyl cellulose.

[0042] When preparing, mix plant glucomannan, methylphenyl silicone oil and flusilazole, and dissolve in 2-3 of polyvinyl alcohol, hydroxyethyl cellulose, hydroxymethyl cellulose, and hydroxymethyl cellulose The ingredients are mixed in a matrix, filled in plastic tubes, sterilized by radiation, and then made into finished products. To use, apply to blemishes.

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PUM

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Abstract

The invention discloses a plant glucomannan silicone dressing. The plant glucomannan silicone dressing is prepared from the following components in percentage by weight: 0.05-5 percent of plant glucomannan, 0.5-50 percent of silicone, 0.1-5 percent of organosilicon antibacterial agent and the balance of matrix. A preparation method of the plant glucomannan silicone dressing comprises the following steps: mixing the plant glucomannan, the silicone and the organosilicon antibacterial agent and dissolving in the matrix; sterilizing and disinfecting through irradiation to prepare a finished product. By using the plant glucomannan silicone dressing, scars can be obviously reduced or prevented from hyperplasia and softening, the color tends to be consistent with the color of surrounding skin, the symptoms of itching and pain are obviously relieved, and the congestion condition is obviously improved, so that the plant glucomannan silicone dressing can be used for inhibiting formation of early skin scars and reducing the mid-term scar hyperplasia and hardness and pigmentation of later scars, and the feelings of itching and pain of scar tissues can be effectively relieved.

Description

technical field [0001] The invention relates to a plant glucomannan silicone dressing and a preparation method and application thereof. Background technique [0002] Scar tissue is a hyperplastic tissue produced during the repair of skin trauma. The scar is higher than the skin, irregular in shape, flushed and congested, hard on the surface, often with pigmentation, and accompanied by pain and itching, which brings inconvenience to the patient's life and affects the appearance. cause psychological and physical burden on patients. Reducing scar tissue hyperplasia is a long-standing goal of the medical profession. Silicone products are commonly used products in the field of scar removal, but their effects are still far from people's requirements. Finding more effective scar removal formulas has important medical significance. The process of scar tissue hyperplasia is a process of inflammatory response and tissue regeneration. Excessive inflammatory response or reaction time...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/30A61L15/26A61L15/20A61L15/44A61L15/42A61L2/08
Inventor 董磊
Owner 合肥博太医药生物技术发展有限公司
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