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Method of producing substances with supersaturated gas, transdermal delivery device thereof, and uses thereof

A technology of transdermal drug delivery and equipment, which is applied in the direction of drug devices, drug devices, and other medical devices, and can solve problems such as patient discomfort

Inactive Publication Date: 2014-02-26
INVISIDERM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, transdermal drug delivery systems on the market today are limited to small daily doses of small molecular weight drugs, often accompanied by various patient discomforts

Method used

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  • Method of producing substances with supersaturated gas, transdermal delivery device thereof, and uses thereof
  • Method of producing substances with supersaturated gas, transdermal delivery device thereof, and uses thereof
  • Method of producing substances with supersaturated gas, transdermal delivery device thereof, and uses thereof

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Embodiment Construction

[0021] The average diameter of most human sweat glands provides a suitable space for the passage of most drug molecules. According to various studies, the average density of sweat gland pores varies significantly between individuals and body parts. There are an average of 2,700 pores per square inch of friction ridge skin surface on the palmar surface, palm and fingers, and on the plantar surface, sole and toe. This compares to approximately 400 pores per square inch on the rest of the human skin surface. It is estimated that the total number of sweat gland pores distributed throughout the body ranges from 1.6 to 4 million. The size of sweat glands varies by a factor of five between individuals, but the average size of pores in human skin is 50 microns. Veins descending from the epidermal opening are about 2 to 5 mm long and 60 to 80 microns in diameter, with tubes of slightly smaller diameter.

[0022] This specification discloses the design of lightweight, hand-held mecha...

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Abstract

The present specification disclosed a noninvasive transdermal delivery device that relates generally to a handheld mechanical apparatus for noninvasive transdermal administration of gas, small to large water- soluble (hydrophilic) pharmaceutical agents, vitamins, and other therapeutic agents. Components of such delivery devices, methods of producing a substance comprising a supersaturated amount of a dissolved gas, as well as, methods of administering a therapeutic agent using such delivery devices and methods of treating a disease or condition using such delivery devices are also disclosed.

Description

Background technique [0001] The generally recognized transdermal drug delivery is to deliver a therapeutic agent through the skin to achieve a therapeutic effect. Transdermal drug delivery systems are dosage forms that facilitate delivery of therapeutic agents to viable epidermal and / or dermal tissues for local therapeutic effect, and through blood circulation for systemic therapeutic effect. Transdermal delivery of therapeutic agents offers several advantages over the injectable and oral routes. For example, transdermal delivery of therapeutic agents increases bioavailability of therapeutic agents by avoiding gastrointestinal absorption and hepatic first-pass metabolism; enhances therapeutic efficiency by providing controlled, constant delivery of therapeutic agents; Delivered therapeutic agent maintains a stable plasma concentration of the therapeutic agent; reduces pharmacological dosage due to better absorption of the therapeutic agent; provides better overall therapeutic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61M11/04A61M11/06
CPCA61M11/04A61M37/00A61M2205/8225A61M2037/0007A61M11/06A61M35/003
Inventor 诺伯特·基什
Owner INVISIDERM