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Preparation method of core-shell structure superfine fiber carrier material for medical dressing

A technology of microfiber, carrier material

Active Publication Date: 2015-05-13
上海必趣医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a method for preparing a core-shell structure microfiber carrier material for medical dressings. The preparation method is easy to operate, the material is easy to obtain, the solvent is non-toxic or low-toxic, and it is safe to handle and use; Structural ultrafine fibers can not only solve the problem of poor fiber-forming polymers that are not easy to spin, but also be able to load drugs and achieve the effect of sustained release of drugs

Method used

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  • Preparation method of core-shell structure superfine fiber carrier material for medical dressing
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  • Preparation method of core-shell structure superfine fiber carrier material for medical dressing

Examples

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Effect test

Embodiment 1

[0030] (1) Take 1g polyvinyl alcohol (the degree of polymerization is 1700, the degree of alcoholysis is 88%) with electronic balance scale and dissolve in 9g ultrapure water, prepare the solution that the mass fraction is 10%, in the water bath of 80 ℃, in the magnetic stirring Stir under the action of a device until completely dissolved to obtain a shell solution;

[0031] (2) take 0.4g chitosan (relative molecular weight 800,000, degree of deacetylation is 95%), 0.04g ciprofloxacin hydrochloride respectively with electronic balance, and dissolve it in 9.6g2% In the acetic acid solution, under the action of magnetic stirrer, stir until completely dissolving to obtain nuclear layer solution;

[0032] (3) using such as figure 1 The electrospinning device shown is for coaxial electrospinning, the feed rate of the core solution is set to 0.06mL / h, the diameter of the inner spinneret is 0.5mm, and the feed rate of the shell solution is 0.6mL / h. The diameter of the outer spinner...

Embodiment 2

[0035](1) Take 1g polyvinyl alcohol (the degree of polymerization is 1700, the degree of alcoholysis is 88%) with the electronic balance scale and dissolve in 9g ultrapure water, prepare the solution that the mass fraction is 10%, in the water bath of about 80 ℃ Stir under the action of a magnetic stirrer until completely dissolved to obtain a shell solution;

[0036] (2) Dissolve 0.1g of sodium alginate in 9.9g of ultrapure water with an electronic balance to obtain a sodium alginate solution with a mass fraction of 1%, and stir it under the action of a magnetic stirrer at room temperature until it is completely dissolved to obtain a nuclear layer solution ;

[0037] (3) using such as figure 1 The electrospinning device shown is for coaxial electrospinning, the feed rate of the core layer solution is set to 0.07mL / h, the diameter of the inner spinneret is 0.5mm, and the feed rate of the shell layer solution is 0.7mL / h. The diameter of the outer spinneret is 1.26mm; the appl...

Embodiment 3

[0040] (1) get 0.36g chitosan (relative molecular weight 800,000, degree of deacetylation is 95%), 0.04g ethylene oxide (relative molecular weight is 900KDa) and dissolve in the acetic acid solution of 9.6g90% with electronic balance scale, obtain mass A solution with a fraction of 4%, was stirred under the action of a magnetic stirrer at room temperature until it was completely dissolved to obtain a shell solution:

[0041] (2) Dissolve 0.1 g of sodium alginate in 9.9 g of ultrapure water with an electronic balance, and stir under the action of a magnetic stirrer at room temperature until completely dissolved to obtain a nuclear layer solution;

[0042] (3) using such as figure 1 The electrospinning device shown is for coaxial electrospinning, the feed rate of the core layer solution is set to 0.07mL / h, the diameter of the inner spinneret is 0.5mm, and the feed rate of the shell layer solution is 0.7mL / h. The diameter of the outer spinneret is 1.26mm; the applied voltage is ...

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Abstract

The invention provides a preparation method of a core-shell structure superfine fiber carrier material for medical dressing. The preparation method is basically characterized by specifically comprising the following steps: mixing and dissolving macromolecular polymers into a solvent to obtain a shell layer solution; selecting at least one of a functional high polymer and a medicine and dissolving the functional high polymer or the medicine into a solvent under the aseptic condition to obtain a core layer solution; and performing coaxial electrostatic spinning, placing into a vacuum drying box, and vacuum-drying to remove the residual solvent to obtain the core-shell structure superfine fiber carrier material for the medical dressing. The core-shell structure superfine fiber carrier material for the medical dressing has excellent water-absorbing property, moisturizing property and air permeability, can provide a wet microenvironment for wound healing, is uniform in pore size distribution, and achieves a bacterium blocking effect. The core layer high polymer or medicine can achieve zero-order release through corrosion or diffusion mechanism, so the influence of the environment on the medicine effect is reduced and unnecessary damage to a human body by the medicine is reduced.

Description

technical field [0001] The invention relates to a method for preparing superfine fibers with a core-shell structure as a medical dressing carrier material by means of coaxial electrospinning technology. Background technique [0002] The ultrafine fiber membrane prepared by electrospinning has the characteristics of fine fiber diameter, large specific surface area, and high porosity. This structural feature shows unique properties when used as a carrier material, and has good applications in drug controlled release and wound repair. prospect. For example, Smith and Reneker sprayed PEO electrospun microfiber directly on the injured part of the skin surface to form a fibrous membrane dressing to promote skin growth. Zuo Fangfang successfully prepared chitosan / polyvinyl alcohol nanofiber medical dressing with excellent biocompatibility and mechanical properties; the patent of publication number CN101158062A discloses the use of polyethylene glycol and sodium alginate to obtain ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H1/728D01D5/00A61L15/28A61L15/24A61L15/44D04H1/4382
Inventor 高晶王璐程凤王晓丽孙立军
Owner 上海必趣医疗科技有限公司
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