Medical chitosan haemostatic wound dressing

A technology of hemostatic dressing and chitosan, which is used in medical science, absorbent pads, bandages, etc., can solve problems such as unsatisfactory hemostatic effect and poor skin fit, and achieve control of severe bleeding, good antibacterial properties, and reduced time. Effect

Inactive Publication Date: 2014-04-02
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the hemostatic dressings that are put into clinical use in the industry generally have problems such as unsatisfactory hemost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Put 40 kg of chitosan, 25 kg of succinyl chitosan, 15 kg of sodium hyaluronate, 5 kg of nano-silver inorganic antibacterial agent, 2 kg of borneol, and 6 kg of diclofenac diethylammonium salt in a stirrer for 10~ 20 min, mix well, sterilize, and bottle.

Embodiment 2

[0020] Weigh 40 kg of chitosan, 25 kg of succinyl chitosan, 15 kg of sodium hyaluronate, 5 kg of nano-silver inorganic antibacterial agent, 2 kg of borneol, and 6 kg of diclofenac diethylammonium salt in the reactor , add 1%~1.5% acetic acid aqueous solution, stir until fully dissolved; add 20kg of sweet potato starch with a purity of more than 95% and 10 kg of analytical grade ethylene glycol, continue stirring and heat at 80~110°C for 15~30 min ; Pour the mixed solution onto the film-making mold, scrape it flat, and after it is fully dried, release the film and package it.

Embodiment 3

[0022] Put 30 kg of chitosan, 25 kg of succinyl chitosan, 10 kg of sodium hyaluronate, 5 kg of nano-zinc oxide, and 8 kg of analgesic and anti-inflammatory agents into a blender and stir for 10-20 min, mix well, and pack bottle.

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PUM

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Abstract

The invention discloses a medical chitosan haemostatic wound dressing and a preparation method thereof. The medical chitosan haemostatic wound dressing comprises the following raw materials in parts by weight: 25-40 parts of chitosan, 10-25 parts of succinyl-chitosan, 5-15 parts of sodium hyaluronate, 1-5 parts of an antibacterial agent, 2-8 parts of anti-inflammatory analgesic, 5-20 parts of starch and 2-10 parts of a plasticizer. The wound dressing provided by the invention is applied in the aspects of medical bleeding promoting, antisepsis and anti-inflammation, wound healing promoting and the like.

Description

technical field [0001] The invention relates to a medical dressing, in particular to a medical chitosan hemostatic dressing and a preparation method thereof. Background technique [0002] Chitin, chitosan and their derivatives have the functions of hemostasis, pain relief, and inhibition of microbial growth, which are all positive for wound healing. At present, the role of chitin, chitosan and their derivatives in promoting wound healing has been proved by many scholars. [0003] The research found that the mechanism of chitosan to promote wound healing is mainly: (1) Accelerate the exudation of PMN cells into the wound area; (2) Accelerate the exudation to form silk fibrin and activate fibroblasts to move to the wound area; ( 3) Stimulate the movement of macrophages; (4) Stimulate the proliferation of fibroblasts and the production of type III collagen fibers. [0004] At present, the hemostatic dressings put into clinical use in the industry generally have problems su...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44
Inventor 徐广苓
Owner QINGDAO MUNICIPAL HOSPITAL
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