Povidone-iodine vaginal swelling suppository, as well as preparation method and detection method thereof

A vaginal expansive suppository and povidone-iodine technology, which is applied in suppository delivery, measuring devices, pharmaceutical formulations, etc., can solve the problems of short validity period, easy volatility, and poor adhesion of suppositories, and achieve the goal of avoiding secondary infection and preventing outflow Effect

Active Publication Date: 2014-04-16
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Prior art discloses the preparation of multiple povidone-iodine, comprises tablet, oral liquid, gel, ointment and suppository etc.; The most widely, the 2010 edition of the Chinese Pharmacopoeia records povidone-iodine suppository, which is clinically used to treat candida vulvovaginosis, bacterial vaginosis and mixed infectious vaginitis, and has achieved remarkable curative effect; in addition, CN102335120 discloses A kind of povidone-iodine effervescent suppository is disclosed, and this suppository comprises povidone-iodine, sodium bicarbonate, tartaric acid, S-40, polyethylene glycol 6000; CN1679621 discloses a kind of povidone-iodine capsule suppository, and it comprises polyvi

Method used

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  • Povidone-iodine vaginal swelling suppository, as well as preparation method and detection method thereof
  • Povidone-iodine vaginal swelling suppository, as well as preparation method and detection method thereof
  • Povidone-iodine vaginal swelling suppository, as well as preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092]

[0093] Preparation:

[0094] 1) Preparation of drug-containing matrix:

[0095] a. placing cocoa butter and carbomer in a water bath for heating and melting to obtain a melt;

[0096] b. adding povidone-iodine to the melt of step a, and mixing uniformly to obtain a drug-containing matrix;

[0097] 2) Preparation of expansive suppositories: Pour the drug-containing matrix into a suppository mold, insert a tampon, cool and shape, and make 100 conical suppositories, each weighing about 3.2g.

Embodiment 2

[0099]

[0100] Preparation:

[0101] 1) Preparation of drug-containing matrix:

[0102] a. heat and melt tallow tallow and alginic acid in a water bath to obtain a melt;

[0103] B. the preparation of povidone-iodine microcapsules: add povidone-iodine in glyceryl stearate and polyvinylpyrrolidone, grind to uniform, make povidone-iodine grind; Add water at a ratio of 1:3 to obtain an aqueous solution; mix the povidone-iodine ground material and the aqueous solution evenly, and emulsify at high speed to obtain povidone-iodine colostrum; place povidone-iodine colostrum in a high-pressure homogenizer Medium emulsification to obtain a povidone-iodine emulsion; the povidone-iodine emulsion is spray-dried to obtain povidone-iodine microcapsules with a particle size range of 5 μm;

[0104] c. adding povidone-iodine microcapsules to the melt in step a, and mixing uniformly to obtain a drug-containing matrix;

[0105] 2) Preparation of expansive suppositories: Pour the drug-conta...

Embodiment 3

[0107]

[0108] Preparation:

[0109] 1) Preparation of drug-containing matrix:

[0110] a. Polyethylene glycol 400 and polyethylene glycol 6000 are heated and melted in a water bath to obtain a melt;

[0111] b. Preparation of povidone-iodine microcapsules: add povidone-iodine to glyceryl stearate and cellulose acetate phthalate, and grind until uniform to obtain povidone-iodine grind; Add water at a volume ratio of 1:3 to obtain an aqueous solution; mix the povidone-iodine ground material and the aqueous solution evenly, and emulsify in high-speed shear to obtain povidone-iodine colostrum; place povidone-iodine colostrum under high pressure Emulsifying in a homogenizer to obtain a povidone-iodine emulsion; spray-drying the povidone-iodine emulsion to obtain povidone-iodine microcapsules with a particle size range of 5 μm;

[0112] c. mix povidone-iodine microcapsules and nonoxynol-10 evenly to prepare a mixture;

[0113] d. Add the mixture of step c to the melt of step...

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Abstract

The invention relates to a povidone-iodine vaginal swelling suppository, as well as a preparation method and a detection method thereof. The swelling suppository comprises a drug-containing matrix formed by povidone-iodine and a matrix, and a swelling carrier, wherein povidone-iodine, a capsule material and pregelatinized starch are used to prepare a micro-capsule, so that the volatilization of povidone-iodine can be reduced, and the effect of slowly releasing a drug can be achieved; nonoxynol-10, polyethylene glycol glyceride octoate caprate, stearyl alcohol and magnesium aluminum silicate are also added into the drug-containing matrix. The prepared swelling suppository is high in stability, and difficult in deformation or rancidity or melting and has good lubricating performance; seven original advanced technologies are adopted, so that the povidone-iodine vaginal swelling suppository has the beneficial effects of preventing liquid medicine from overflowing, avoiding secondary infection and the like.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a povidone-iodine vaginal expansive suppository and a preparation method and a detection method thereof. Background technique [0002] Povidone-iodine, the chemical name is a compound of 1-vinyl-2-pyrrolidone homopolymer and iodine, the effective content of iodine is 9-12%; it is a yellow-brown to reddish-brown amorphous powder; in water or ethanol Dissolved, insoluble in ether or chloroform. [0003] Prior art discloses the preparation of multiple povidone-iodine, comprises tablet, oral liquid, gel, ointment and suppository etc.; The most widely, the 2010 edition of the Chinese Pharmacopoeia records povidone-iodine suppository, which is clinically used to treat candida vulvovaginosis, bacterial vaginosis and mixed infectious vaginitis, and has achieved remarkable curative effect; in addition, CN102335120 discloses A kind of povidone-iodine effervescent suppository is discl...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K31/79A61K47/36A61K47/32A61K47/38A61K47/14A61P15/02A61P31/04A61P31/10G01N33/15G01G17/00
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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