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A kind of industrial extraction method of heme in sun-dried pig blood meal in slaughterhouse

An extraction method and a technology of pig blood meal, which are applied in the direction of iron group organic compounds without C-metal bonds, organic chemistry, iron organic compounds, etc., can solve the problems of loss of active components of pig blood, difficulty in solvent recovery, high extraction cost, etc., to achieve Solve the difficulty of recycling, easy recycling and application, and high extraction rate

Active Publication Date: 2016-01-13
ZHONGSHAN BAILING BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method needs to use glacial acetic acid for crystallization, the solvent recovery is difficult, and the chlorination process needs to use a high temperature of 100 ° C, and the extraction cost is high
[0009] Existing technology for extracting amino acids from pig blood meal, the filter residue of pig blood meal after extraction is generally discarded, resulting in the loss of most of the active ingredients in pig blood

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A method for industrialized extraction of hemoglobin in sun-dried pig blood powder of a slaughterhouse of the present invention comprises the following steps:

[0036] A. One-stage extraction of heme:

[0037]Dry the sun-dried pig blood meal in the slaughterhouse, add diethylamine and methanol, and the mass volume ratio of pig blood meal to diethylamine and methanol is pig blood meal (g): diethylamine (ml): methanol (ml) = 1 :0.33:3, heat up to 30°C, stir and extract for 1 hour; filter, and vacuum-dry the porcine blood powder filter residue at 40°C, distill the filtrate to dryness under reduced pressure and recover most of the solvent. ): hydrochloric acid (ml) = 1:1 mass volume ratio, add 5% hydrochloric acid solution to the mixture of residue after evaporation to dryness and pig blood meal filter residue; heat up to 50°C, stir and reflux for 1 hour, cool down to 7 Stand at ℃ for 1 hour to crystallize, and filter to obtain steel-blue flashing needle-shaped heme crysta...

Embodiment 2

[0043] A method for industrialized extraction of hemoglobin in sun-dried pig blood powder of a slaughterhouse of the present invention comprises the following steps:

[0044] A. One-stage extraction of heme:

[0045] Dry the sun-dried pig blood meal in the slaughterhouse, add diethylamine and methanol, and the mass volume ratio of pig blood meal to diethylamine and methanol is pig blood meal (g): diethylamine (ml): methanol (ml) = 1 :1:18, heat up to 80°C and stir for 6 hours; filter, and vacuum-dry the porcine blood powder filter residue at 80°C, distill the filtrate to dryness under reduced pressure and recover most of the solvent. ): hydrochloric acid (ml) = 1:6 mass volume ratio, add 20% hydrochloric acid solution to the mixture of residue after evaporation to dryness and pig blood meal filter residue; heat up to 100°C, stir and reflux for 4 hours, cool down to 20°C Stand at ℃ for 10 hours to crystallize, and filter to obtain steel blue flashing needle-shaped heme crystal...

Embodiment 3

[0051] A method for industrialized extraction of hemoglobin in sun-dried pig blood meal of a slaughterhouse of the present invention comprises the following steps:

[0052] A. One-stage extraction of heme:

[0053] Dry the sun-dried pig blood meal in the slaughterhouse, add diethylamine and methanol, and the mass volume ratio of pig blood meal to diethylamine and methanol is pig blood meal (g): diethylamine (ml): methanol (ml) = 1 :0.5-1:12, heat up to 30-80°C, stir and extract for 4 hours; filter, vacuum-dry the pig blood meal filter residue at 460°C, distill the filtrate to dryness under reduced pressure and recover most of the solvent, press the residue after evaporation to dryness and pig blood meal filter residue The mixture (g): hydrochloric acid (ml) = 1:2 mass volume ratio, add a 10% hydrochloric acid solution to the mixture of the residue after evaporation to dryness and the filter residue of pig blood meal; heat up to 70°C, stir and reflux for 2 hours , cooled to 10...

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PUM

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Abstract

The invention discloses a method for industrially extracting protoheme from solarized swine blood meal in a slaughter house. The method is characterized by comprising the following steps: A, performing first-stage extraction of protoheme; B, performing second-stage extraction of the protoheme; C, performing third-stage extraction of the protoheme. By adopting the simple-process and low-cost method for industrially extracting protoheme from solarized swine blood meal in the slaughter house, the defects in the prior art are overcome, the problem of recovery of solvents can be solved effectively, the raw material utilization ratio can be utilized comprehensively, and the extraction efficiency of the protoheme is increased.

Description

technical field [0001] The invention relates to an industrialized extraction method for heme in sun-dried pig blood meal in slaughterhouses. Background technique [0002] Heme alias high iron hemoglobin, heme iron, hydroxyheme, hydroxymetherin, ferric protoporphyrin. The molecular formula is Cs H 33 FeN·O, the molecular weight is 633.49. Heme is a porphyrin compound containing iron. The iron atom is located in the center of the porphyrin ring, has a conjugated structure, and is stable in nature. Heme is soluble in sodium hydroxide solution, hot alcohol or ammonia, slightly soluble in hot pyridine, insoluble in water, dilute acid, ether, chloroform and acetone. It decomposes at 200°C and has no melting point. The maximum absorption value is 580nm in 10% sodium hydroxide solution. Heme is a reddish-purple long flaky crystal, and its color varies greatly with the purification solvent used. May be black green solid powder or brown powder. Heme is relatively stable in a dry...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D487/22
CPCC07F15/025
Inventor 阮宇峰张和平梁待亮王明宗沈惠宾曾湘华黄文军周海香娄良刘骅刘杰
Owner ZHONGSHAN BAILING BIOTECHNOLOGY CO LTD
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