A kind of compound Yimu capsule and preparation method thereof

A technology of capsules and Yimu, which is applied in the field of compound Yimu capsules and its preparation, can solve problems such as low cure rate, inability to regulate endocrine, and damage the body, and achieve the effect of improving efficacy

Active Publication Date: 2017-06-06
XIANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current western medicine treatment is mainly a general hemostatic measure, which cannot fundamentally start from the regulation of endocrine, and it is harmful to the body, easy to relapse, and has obvious side effects
At present, there are some therapeutic drugs based on Chinese herbal medicines on the market, such as Motherwort Capsules of Shandong Xiangyu Pharmaceutical, which overcomes some side effects caused by western medicines, but there are also problems such as insufficient curative effect, low cure rate, easy relapse, and technical problems. Defects such as thicker

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  • A kind of compound Yimu capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A compound Yimu capsule, which comprises the following four medicinal materials: 1084g of motherwort, 544g of angelica, 272g of Chuanxiong, and 100g of cayenne; the preparation method of the compound Yimu capsule is carried out according to the following steps:

[0019] Take 1084g of motherwort, add water and decoct twice, collect the decoction for the first 3 hours, collect the decoction for the second 2 hours, combine the decoctions of the two decoctions, filter, concentrate the filtrate, and control the temperature during the concentration process to 75-95 ℃, the concentrated paste is controlled at a relative density of 1.12-1.14g / ml (measured at 60°C), then add ethanol to the concentrated paste to make the content of ethanol 60%, stir well, refrigerate at 4°C for 24 hours, filter Collect the filtrate, and finally reclaim ethanol from the filtrate to obtain the motherwort concentrate for subsequent use;

[0020] Take 544g of Angelica sinensis, 272g of Chuanxiong Rhiz...

Embodiment 2

[0023] A compound Yimu capsule, which comprises the following seven medicinal materials: 1084g of motherwort, 544g of angelica, 272g of Rhizoma Chuanxiong, 100g of woody fragrance, 89g of mulberry leaves, 62g of saffron, and 36g of dandelion; the preparation method of the compound Yimu capsule is carried out according to the following steps:

[0024] Take 1084g motherwort and add water to decoct twice, the first time is 3 hours, the second time is 2 hours, the decoctions are combined, filtered, and the filtrate is concentrated. The relative density of the concentrated paste is 1.12-1.14g / ml measured at 60°C. The process control temperature is 75-95°C, add ethanol to the concentrated ointment to make the ethanol content 60%, stir well, refrigerate at 4°C for 24 hours, filter, recover the ethanol from the filtrate, and obtain the motherwort concentrate for later use;

[0025] Take 544g of Angelica sinensis, 272g of Rhizoma Chuanxiong, 100g of woody fragrance, 89g of mulberry leav...

Embodiment 3

[0028] Analgesic experiment

[0029] Animal experiment: 80 Kunming female mice, weighing 18-22g. Divide into blank control group (distilled water, 20ml / kg) at random, control drug group: commercially available motherwort capsule (production of Nantong Huashan Pharmaceutical Co., Ltd.) (0.5g / kg), embodiment 1 drug group (0.5g / kg), Example 2 Drug group (0.5g / kg), 20 animals in each group. 30 minutes after intragastric administration of mice in each group, each mouse was intraperitoneally injected with 0.65% glacial acetic acid, 0.2ml per mouse, and the average number of writhing times of each mouse within 15 minutes after injection of glacial acetic acid was observed.

[0030] The test results are as follows:

[0031] Table 1 Drug of the present invention is tested on mouse analgesia

[0032] group Number of mice (only) Average number of twists (30min) saline group 20 38.65 control drug group 20 12.76 Embodiment 1 drug group 20 9.89 Embo...

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Abstract

The invention relates to a compound Yimu capsule and a preparation method thereof. The capsule is prepared from the following four medicinal materials: 1,084 g of Leonurus japonicus, 544 g of Angelica sinensis, 272 g of Ligusticum chuanxiong, and 100 g of Aucklandia lappa. zlThe invention also discloses a method for preparing the compound Yimu capsule. According to the preparation method, the preparation process parameters of Yimu capsule are optimized; through controlling temperature, ethanol reflux time and the like, the efficacy of Yimu capsule is improved, the drug effects of traditional Chinese medicinal components are fully exerted, and wide application prospects are realized.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a compound Yimu capsule and a preparation method thereof. Background technique [0002] Irregular menstruation or dysmenorrhea refers to menstrual changes caused by various reasons. Many reasons can cause irregular menstruation, such as endocrine disorders or certain diseases of their own. Greed for cold, overwork, excessive dieting, addiction to tobacco and alcohol, emotional abnormalities, high stress, etc. Taking certain drugs can also cause irregular menstruation. In recent years, with the fast pace of life and high work pressure in modern society, it is easy to cause anxiety, depression, and irritability in women. Women mainly use blood, and blood flows with Qi, and irregular menstruation is caused by emotional changes. The symptoms of irregular menstruation include the following points. 1. Menorrhagia, bleeding is cyclical, often accompanied by prolonged menst...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/533A61K36/88A61P15/00
Inventor 林凡友
Owner XIANGYU PHARMA
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