Glowing nanometer fibre with biocompatibility and preparation method of glowing nanometer fibre

A biocompatibility and nanofiber technology, which is applied in the preparation of fluorescent nanofibers, luminescent nanofibers and its preparation, can solve the problems that fluorescent nanofibers are not suitable for the biological field and do not have biological safety, so as to facilitate later observation , good biocompatibility, and the effect of luminescent performance

Inactive Publication Date: 2014-05-21
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

In this new method called Electrospinning (ES), it allows creation of small particles that are made up from tiny polymer chains without any harm or damage they might cause during manufacturing processes. These nanoparticles have excellent fluorescent qualities making them ideal materials used in biomedics like biosensors due their ability to detect changes caused by external stimuli such as light exposure. They could be useful as templates when needed afterward. Overall, these methods provide an efficient way to make complex structures with high precision at affordable prices while maintaining its beneficial attributes.

Problems solved by technology

This patented technical problem addressed in this patents relates to developing applications related to conductive spun filaments (CF) and their composites called clothing fabrics. These CFs provide excellent mechanical strength while maintaining biocompatibility due to strong electrical forces generated during charging/discharging processes. They may find potential medical applications like implants for regenerative medicine and drug carrying agents.

Method used

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  • Glowing nanometer fibre with biocompatibility and preparation method of glowing nanometer fibre
  • Glowing nanometer fibre with biocompatibility and preparation method of glowing nanometer fibre
  • Glowing nanometer fibre with biocompatibility and preparation method of glowing nanometer fibre

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1) Dissolve 0.5 g, 100 nanometer carbon nanoparticles in 10 ml of water under ultrasonic conditions for 0.5 hours to make the mass concentration 0.05 g / ml. Under stirring conditions, 1 g of polyvinylpyrrolidone was added and stirred for 1 hour to finally obtain a uniform spinning solution.

[0023] 2) Pour the above spinning solution into the syringe, adjust the voltage to 10 kV, the solution flow rate is 0.1 ml / h, and the receiving distance is 10 cm. A uniform layer of white fiber is collected on the receiving aluminum foil.

[0024] 3) Put the white fibers in a high-temperature tubular atmosphere furnace, ventilate nitrogen, increase the temperature to 600°C, keep the temperature for 3 hours, and finally decrease the temperature to room temperature to obtain luminescent nanofibers containing carbon nanoparticles.

[0025] figure 1 Scanning electron micrograph of the prepared nanofiber membrane. It can be seen from the figure that the diameter of the nanofiber is 500 nanomet...

Embodiment 2

[0027] 1) Dissolve 1 gram of 300-nanometer carbon nanoparticles in 10 ml of 1:1 ethanol / chloroform under ultrasonic conditions for 1 hour to achieve a mass concentration of 0.1 g / ml. Under stirring conditions, 0.5 g of polylactic acid was added and stirred for 2 hours to finally obtain a uniform spinning solution.

[0028] 2) Fill the above-mentioned spinning solution into the syringe, adjust the voltage to 15 kV, the solution flow rate is 0.1 ml / h, and the receiving distance is 10 cm. A uniform layer of white fiber is collected on the receiving aluminum foil.

[0029] 3) Put the white fibers in a high-temperature tubular atmosphere furnace, blow in nitrogen, raise the temperature to 800°C, keep the temperature for 2 hours, and finally lower the temperature to room temperature to obtain luminescent nanofibers containing carbon nanoparticles.

[0030] figure 2 Scanning electron micrograph of the prepared nanofiber membrane. It can be seen from the figure that the diameter of the nan...

Embodiment 3

[0032] 1) Dissolve carbon nanoparticles of 0.1 g and 200 nanometers in 10 ml of ethanol under ultrasonic conditions for 1 hour to make the mass concentration 0.01 g / ml. Under stirring conditions, 0.2 g of chitosan was added and stirred for 3 hours to finally obtain a uniform spinning solution.

[0033] 2) Fill the above-mentioned spinning solution into the syringe, adjust the voltage to 20 kV, the solution flow rate is 0.2 ml / h, and the receiving distance is 15 cm. A uniform layer of white fiber is collected on the receiving aluminum foil.

[0034] 3) Put the white fibers in a high-temperature tubular atmosphere furnace, blow in nitrogen, increase the temperature to 600°C, keep the temperature for 2 hours, and finally decrease the temperature to room temperature to obtain luminescent nanofibers containing carbon nanoparticles.

[0035] image 3 It is the emission spectrum of nanofiber membrane with 800 nm as the excitation wavelength. It can be seen from the figure that the emission...

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Abstract

The invention relates to a preparation method of a glowing nanometer fibre with the biocompatibility. The preparation method comprises the following steps of dissolving carbon nanometer particles in a solvent, adding a high molecular material under a stirring condition in the mass ratio of the high molecular material to the carbon nanometer particles being (0.5:1)-(1:2), and stirring for 1-3 hours so as to obtain a uniform spinning fluid ultimately; injecting a spinning liquid into a needle cylinder, regulating an electrostatic spinning technology, collecting a layer of uniform white fibres which are collected from a receiving aluminum foil; and putting the white fibres into a high-temperature pipe-shaped atmosphere furnace, inputting nitrogen, heating to 600-1000 DEG C, carrying out heat preservation for 1-5 hours, and finally cooling to the room temperature so as to obtain the glowing nanometer fibre containing the carbon nanometer particles. The obtained fibre has the good biocompatibility, meanwhile, the fibres have a glowing property, the glowing nanometer fibre is suitable for being used in a biomedical field, and the glowing nanometer fibre is particularly utilized as a bracket material and is convenient to anaphase observation. The preparation method provided by the invention is simple, the production cost is low, and the preparation method can further meet the production and application requirements.

Description

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Claims

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Application Information

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Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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