Lactobacillus paracasei NCC2461 (ST11) for use by perinatal maternal administration in the reduction and prevention of allergies in progeny

A paracheese, Lactobacillus technology, applied in the directions of Lactobacillus, bacteria used in food preparation, allergic diseases, etc., can solve the problem of probiotic treatment not producing predictable results, etc.

Inactive Publication Date: 2014-05-28
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] However, recent reports demonstrate that perinatal and / or postpartum probiotic treatment does not produce predictable outcomes

Method used

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  • Lactobacillus paracasei NCC2461 (ST11) for use by perinatal maternal administration in the reduction and prevention of allergies in progeny
  • Lactobacillus paracasei NCC2461 (ST11) for use by perinatal maternal administration in the reduction and prevention of allergies in progeny
  • Lactobacillus paracasei NCC2461 (ST11) for use by perinatal maternal administration in the reduction and prevention of allergies in progeny

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] Using a mouse model of birch pollen allergy suggests that maternal supplementation with ST11 will protect offspring from an allergic phenotype.

[0118] BALB / c mice received ST11-containing drinking water daily during the last week of gestation and during lactation. Pregnant and lactating female mouse mothers were fed daily with drinking water containing live probiotic strain ST11. Offspring of ST11-treated or sham-treated dams were sensitized with the recombinant major birch pollen allergen Bet v1 and challenged with birch pollen extract ( figure 1 experimental design).

[0119] animal:

[0120] Pregnant BALB / c mice (gestation day 14) were purchased from Charles River (Sulzfeld, Germany) and maintained under conventional housing conditions. Female TLR2- and TLR4-deficient and wild-type mice with a C57BL / 6 genetic background were obtained from the University of Veterinary Medicine of Vienna (Austria). All experiments were approved by the Animal Experimentation Comm...

Embodiment 2

[0137] Examples of the composition of infant formulas for use according to the invention are provided below. This composition is given by way of illustration only. The protein source is a conventional blend of whey protein and casein protein.

[0138]

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Abstract

The present invention provides a probiotic, Lactobacillus paracasei NCC 2461, i.e. ST11, for use by administration to expectant females and/or lactating mothers, and to their progeny for the reduction or prevention of the development of allergic immune responses in progeny. A daily dose of ST11 is administered to a pregnant woman for at least two weeks before delivery and, after delivery, the daily dose of ST11, is administered to the lactating mother or the newborn infant for at least two months, either directly or via the mother's milk. The infant immune responses to allergens are thus reduced, resulting in a "dampened" allergic response. Thus allergy, including atopy, may be prevented in the progeny.

Description

field of invention [0001] The present invention relates to the perinatal administration of probiotics capable of modulating the infant's immune response to allergens. Background of the invention [0002] The incidence of allergic diseases has increased rapidly in recent decades. Since more than one-third of the world's population suffers from allergies today, it has been considered a new epidemic in industrialized countries. The reasons for the steady increase in allergic diseases are not well understood. The genetic background of the host is a major factor, and recently discovered genes have been shown to be associated with respiratory allergy / asthma and skin symptoms [Holloway, J.W. et al., (2010); Genetics of Allergic Disease, J.A.C.I., 125:S81-94]. Environmental factors such as lifestyle, pollution, reduced family size, and reduced microbial stimulation of the immune system in the early stages of life due to improved hygiene also appear to play an important role. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A23L1/30A61P37/08
CPCA23V2002/00A61K35/74A23L33/40A23L33/135A61P37/08A23V2200/304A23V2400/165
Inventor A·梅赛尼尔A·齐歇尔S·努特恩U·维德曼I·沙布索瓦
Owner NESTEC SA
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