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Solid preparation swelling pressure determination device and method

A technology for solid preparations and measuring devices, applied in measuring devices, force/torque/work measuring instruments, instruments, etc., can solve the problems of irregular shape, undetectable, small size, etc., and achieve easy operation, high sensitivity, and good scientific research. and economic value

Active Publication Date: 2014-06-11
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solid preparations are usually irregular in shape, small in size, and low in expansion pressure, which cannot be detected on existing rock expansion pressure instruments and other equipment; at the same time, the generation rate of expansion pressure of solid preparations is greatly affected by the rate of water ingress and initial pressure. The instrument cannot simulate
So far there is no report about the device and method for measuring the expansion pressure of solid preparations

Method used

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  • Solid preparation swelling pressure determination device and method
  • Solid preparation swelling pressure determination device and method
  • Solid preparation swelling pressure determination device and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: Constant volume expansion pressure measuring device

[0037] Such as figure 1 The shown constant volume expansion pressure measurement device includes a fixed seat 1, a height adjustment structure 2, a mold 3, a probe 4 used in conjunction with the mold 3, and a pressure sensor 5. The height adjustment structure 2 is composed of a screw and a nut, and the mold 3 passes through The cooperation between the screw and the nut is fixed with the fixed seat 1, the pressure sensor 5 is fixed with the fixed seat 1, and the top of the mold 3 is also equipped with a water-permeable structure 6, which is composed of a water-permeable membrane 61 and a water-permeable gasket 62, and the water-permeable structure 6 passes through the lock. The tightening structure 7 is fixed with the mold 3, wherein the locking structure 7 is composed of a screw rod, a nut and a pressing block.

[0038] In this embodiment, the diameter of the probe 4 is 5-12mm, the inner diameter of...

Embodiment 2

[0040] Example 2: Height-fixed expansion pressure measuring device

[0041] Such as diagram 2-1 The height-fixed type measuring device for membrane-controlled sample expansion pressure includes a fixed seat 1, a height adjustment structure 2, a mold 3, a probe 4 matching the inner diameter of the mold 3, and a pressure sensor 5. The height adjustment structure 2 is composed of a screw and a nut, the mold 3 is fixed to the fixed seat 1 through the cooperation of the screw and the nut, the pressure sensor 5 is fixed to the fixed seat 1, and a permeable structure 6 is installed on the top of the mold 3, and the permeable structure 6 is composed of a permeable gasket 62. The permeable structure 6 is fixed to the mold 3 through the locking structure 7, wherein the locking structure 7 is composed of a screw, a nut and a pressing block, and the fixing seat 1, the height adjustment structure 2, the mold 3, the probe 4 and the locking structure 7 are all made of stainless steel Made...

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Abstract

The invention relates to a solid preparation swelling pressure determination device and method. The solid preparation swelling pressure determination device comprises a fixing base, a height adjusting structure, a mold, a probe and a pressure receptor, the probe is matched with the inner diameter of the mold, the mold is fixedly connected with the fixing base through the height adjusting structure, the pressure receptor is fixedly connected with the fixing base, and a water permeable structure is further arranged at the top of the mold, fixedly connected with the mold through a locking structure, formed by a water permeable film and a water permeable gasket or only formed by the water permeable gasket. The solid preparation swelling pressure determination method includes the following steps: (1) selecting the mold and the probe, and measuring the contact area S between a sample and the probe, (2) assembling the sample, (3) conducting zero setting, (4) setting the initial pressure F0, and (5) adding water, conducting zero setting on the pressure receptor, recording displayed numbers F of the pressure receptor at different time points, and calculating the corresponding swelling pressure P according to P=F / S to obtain the t-P curve. The determination device and method are high in sensitivity and easy and convenient to operate, and has the good scientific research and economic value.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and mechanics, and in particular relates to a measuring device and a measuring method for expansion pressure of solid preparations. Background technique [0002] At present, there are many literatures at home and abroad to study the expansion pressure of tablets and capsules, aiming at controlling product quality or realizing various new functions such as pulse, but there is still no corresponding quantitative detection device. Bussemer et al. (Bussemer T , Dashevsky A , Bodmeier R . A pulsatile drug delivery system based on rupturable coated hard gelatin capsules[J].J Controlled Release , 2003,93:331-339.) designed a drug delivery system based on hard gelatin capsules. The drug delivery system is divided into drug core, swelling layer and water-insoluble polymer outer film from the inside to the outside. When the water penetrates into the system through the outer film, it contacts the s...

Claims

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Application Information

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IPC IPC(8): G01L5/00
Inventor 杨燕苗孔颂单伟光
Owner ZHEJIANG UNIV OF TECH
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