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Preparation of multivesicular liposomes composed of squalene and astaxanthin and its reduction of base and damage

A multivesicular liposome and astaxanthin technology, applied in the chemical field, can solve the problems of small particle size, hard outer wall, and unreported microcapsules, and achieve the effects of large surface area, strong air permeability, and increased stability

Active Publication Date: 2016-04-13
CHINA TOBACCO GUANGXI IND +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The microcapsules have small particle size, hard outer wall and poor air permeability, so they are not suitable for use in cigarette filters
[0009] The research on processing these free radical scavengers into multivesicular liposomes and putting them into cigarette filters to scavenge gaseous free radicals (reduced radicals) has not been reported so far, let alone the research based on the synergistic composition of squalene and astaxanthin. Preparation technology and application report of multivesicular liposome

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Prepare each component according to the following parts by mass: 18 grams (g) of hydrogenated lecithin; squalene (Shanghai Xinran Biotechnology Co., Ltd., with a content greater than 96.0%, the same as the following examples. But this does not limit the present invention, Those skilled in the art can use 5 grams (g) of squalene from other sources; , those skilled in the art can use other sources of astaxanthin) 42 grams (g); polyethylene glycol 40,015 grams (g); medium molecular weight (130,000-200,000 Daltons) hydroxyethyl starch 20 grams (g).

[0052] The preparation steps are:

[0053] S1. Dissolve hydrogenated phospholipids, squalene and astaxanthin in 100mL propylene glycol to obtain a mixed system;

[0054] S2. Transfer the mixed system obtained in S1 into 50mL water containing 15g of polyethylene glycol 400, and homogenize at a high speed (2000r / min, 30min) to make it fully mixed to obtain a homogenized mixed system;

[0055] S3. Add hydroxyethyl starch to the ...

Embodiment 2

[0059] Prepare each component according to the following parts by mass: 18 grams of hydrogenated soybean lecithin; 10 grams of squalene; 37 grams of astaxanthin; 15 grams of stearyl alcohol; .

[0060] The preparation steps are:

[0061] S1. Dissolve hydrogenated soybean lecithin, squalene and astaxanthin in 100 milliliters (mL) of propylene glycol to obtain a mixed system;

[0062] S2. Transfer the mixed system obtained in S1 into 50 mL of water containing 15 g of stearyl alcohol, homogenize at a high speed to make it fully mixed, and obtain a homogenized mixed system;

[0063] S3. Add hydroxyethyl starch to the homogenized mixing system obtained in S2 and stir evenly to form a stable particle suspension;

[0064] S4. Freeze-drying the microparticle suspension obtained in S3 to obtain multivesicular liposomes containing squalene and astaxanthin.

Embodiment 3

[0066] Prepare each component according to the following mass parts: 18 grams of hydrogenated lecithin and hydrogenated soybean lecithin; 20 grams of squalene; 27 grams of astaxanthin; 15 grams of glycerin; 20 grams of starch.

[0067] The preparation steps are:

[0068] S1. Dissolve hydrogenated soybean lecithin, squalene and astaxanthin in 100 milliliters (mL) of propylene glycol to obtain a mixed system;

[0069] S2. Transfer the mixed system obtained in S1 into 50 mL of water containing 15 g of glycerin, homogenize at a high speed to make it fully mixed, and obtain a homogenized mixed system;

[0070] S3. Add hydroxyethyl starch to the homogenized mixing system obtained in S2 and stir evenly to form a stable particle suspension;

[0071] S4. Freeze-drying the microparticle suspension obtained in S3 to obtain multivesicular liposomes containing squalene and astaxanthin.

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PUM

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Abstract

The invention discloses a preparation method of a squalene and astaxanthin composite multivesicular liposome and a radical lowering and harm reducing method thereof. The multivesicular liposome is prepared from 12-18 parts of hydrogenated phospholipid, 10-20 parts of stabilizer, 10-15 parts of surfactant and the balance of squalene and astaxanthin composite. Through microencapsulating the squalene and astaxanthin composite, the defect that the squalene and astaxanthin composite is easily oxidized in the air and loses effectiveness is overcome, and the effect of increasing the stability of a squalene and astaxanthin blending synergy composite is achieved. The multivesicular liposome is built in a cigarette filter tip made of cellulose acetate fiber in the forming process of a cigarette filter tip bar, and 0.5-1.5g of multivesicular liposomes is arranged in each cigarette filter tip, so that a cigarette filter tip capable of lowering the harm of cigarettes is obtained; the surface area of the multivesicular liposome is large, so that anti-oxidant makes full contact with main stream smoke, gas-phase free radical in the main stream smoke can be effectively removed, and powerful technical support is provided for solving the smoking and health problem.

Description

technical field [0001] The invention relates to the technical field of chemistry, and more specifically relates to a multivesicular liposome containing a composition of squalene and astaxanthin, a preparation method thereof, and an application in cigarette base reduction and harm reduction. Background technique [0002] Thousands of compounds produced by smoking and the harm caused by high concentration of free radicals to the human body have attracted widespread attention. Free radicals have the strongest effect on the body and are the most harmful. They can cause lung disease, heart disease and cancer. These free radicals can cause serious damage to smokers. Smoking produces high concentrations of free radicals, including relatively long-lived solid-phase free radicals, quinones and semiquinones, polycyclic aromatic hydrocarbons free radicals, and reactive oxygen free radicals produced by their reactions with oxygen such as superoxide anion (O 2 - ), hydrogen peroxide (H...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A24D3/14
Inventor 张雨夏江定心陈泽鹏金亚波韦建玉刘启斌邓宾玲胡亚杰张纪利龙晓彤苏赞
Owner CHINA TOBACCO GUANGXI IND
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