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Active construction method of cell immunological memory at early stage of development of human body
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A technology of cellular immunity and human development, applied in the fields of mammalian medical raw materials, allergic diseases, drug combinations, etc., can solve problems such as coercive methods of destroying the immune system
Inactive Publication Date: 2014-06-18
TSINGHUA UNIV
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Problems solved by technology
[0003] On the other hand, injection of various vaccines in the early stages of human life, such as infancy / childhood and even intrauterine injections, has become a generally accepted routine medical method, but the program of using therapeutic cells and their derivatives to obtain immune memory has not been practiced. In any application, organ transplantation is still a coercive method that can only use drugs to destroy the immune system
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Experimental program
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Effect test
Embodiment 1
[0024] Chicken embryos injected with β-actin-labeled fluorescent BALB / C mice
[0025] Experimental Materials:
[0026] Laihang chicken and Beijing oil chicken eggs
[0029] Take the aforementioned fetal mouse bone marrow, heart and liver, etc. After lysing red blood cells, washing, resuspending in PBS, etc., inject it on the embryo in the hatching egg, and then continue to hatch. After single cells, the content of mouse cells was determined.
[0030] Experimental results:
[0031] After mouse bone marrow cells are injected into chicken embryos, the developed chicken bone marrow and peripheral blood contain mouse cells, which proves that the foreign cells injected during the embryonic period are not affected by the immune system and can continue to multiply and expand in mature chickens in the future. Cell therapy function.
[0032] Chicken embryos injected with fetal mouse heart or liver cells cannot...
Embodiment 2
[0034] Chicken Embryo Injection of Human CD+34 Umbilical Cord Hematopoietic Stem Cells
[0035] Experimental Materials:
[0036] Laihang chicken and Beijing oil chicken eggs
[0037] Human CD+34 umbilical cord hematopoietic stem cells
[0038] Experimental steps:
[0039] Human umbilical cord blood is taken, and after a series of treatments, CD+34 hematopoietic stem cells are extracted by magnetic beads, (purity is higher than 90%), injected on the embryos in hatching eggs, and half of them are kept for freezing, and then continue to incubate, and hatch out after 21 days After the chick, the blood, bone marrow and corresponding organs were collected to separate single cells, and the content of cells carrying human tissue antigens was determined
[0040] Experimental results:
[0041] After the injection, the chicken embryos developed with human cells in the peripheral blood, which proves that the injected cells in the embryonic stage can be successfully integrated into th...
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Abstract
The invention discloses an active construction method of cellimmunological memory at the early stage of the development of a human body. The active construction method comprises the following steps: at the stage before mature and improvement of an immune system of a human body, all the types of cells which can be used for function enhancement or therapy of the cells / stem cells in the past, at current or in future are planted into the human body for single time or multiple times to carry out active (i.e., artificial) construction of the immunological memory and make active preparation of the immunological memory for cell therapy or organ transplantation, and the human body finishing the immunological memory does not generate rejection reaction to therapeutic cells with the memory or generate resistance to a transplanted organ in future. The active construction method disclosed by the invention has the advantages that for a single body actively constructed by immunological memory, when the therapeutic cells / stem cells need to be used in future, the immunological rejection does not occur in future, so that the active construction method is an invention for laying the foundation for treatment of cells / stem cells and has important theoretical and application value.
Description
technical field [0001] The invention relates to the field of cell / stem cell function strengthening / treatment, and in particular to a method for actively constructing cellular immune memory in the early stages of human development. Background technique [0002] At present, cell / stem cell function enhancement / treatment is the frontier field of medicine. Laboratories, scientific research institutions, universities and companies all over the world engaged in research in this area account for the vast majority of the medical field. However, the problem of immune tolerance of cells has not been solved. The method of destroying the immune system by drugs in organ transplantation is not worth the candle, and it cannot be applied to the field of cell / stem cell function enhancement / treatment, and many cell / stem cell function enhancement / treatments can only stay at the theoretical stage. [0003] On the other hand, injection of various vaccines in the early stages of human life, such a...
Claims
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Application Information
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