Five-ester dropping pill and preparation method thereof

A technology of ester dripping pills and southern schisandra, which is applied in pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of insufficient moldability and long dissolution time of five ester dripping pills, and achieve good molding Sexuality and solubility, good for dissolving, easy to take

Active Publication Date: 2014-06-18
CHENGDU RUNHUATANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in the current industrialized production, the five-ester dripp...

Method used

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  • Five-ester dropping pill and preparation method thereof
  • Five-ester dropping pill and preparation method thereof
  • Five-ester dropping pill and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take the medicinal material of Schisandra chinensis and add 6.5 times the weight of Schisandra chinensis to extract with water for 1 hour; filter, discard the filtrate, dry the dregs at 60°C until the weight is reduced by 15%, crush the dried dregs roughly, and then extract with 70% ethanol under reflux 1 time, the amount of ethanol is 6 times the weight of the coarsely crushed medicinal residues, and the extraction is 0.5 hours each time; filter, combine the filtrate, and concentrate under reduced pressure (70°C, -0.07Mpa) to 60°C with a relative density of 1.25. Paste, take 1.125g of Schizandrin extract (calculated as schisandrin A), add it to 22g of molten polyethylene glycol 6000, mix well, raise the temperature to a dropping temperature of 90°C, and drop it into liquid paraffin at 5°C , after molding, drain the liquid paraffin, that is.

Embodiment 2

[0016] Take the medicinal material of Schisandra chinensis and add 7 times the weight of Schisandra chinensis to extract in water for 1.5 hours; filter, discard the filtrate, dry the dregs at 65°C until the weight is reduced by 15%, crush the dried dregs roughly, and then extract with 70% ethanol under reflux 2 times, each time the amount of ethanol is 7 times the weight of the coarsely crushed medicinal residues, and each extraction is 0.7 hours; filter, combine the filtrates, and concentrate under reduced pressure (70°C, -0.07Mpa) to 60°C with a relative density of 1.31. Paste, take 1.125g of Schizandrin extract (calculated as schisandrin A), add it to 24.4g of molten polyethylene glycol 6000, mix well, raise the temperature to 91°C, drop into liquid paraffin at 6°C After forming, drain the liquid paraffin to get it.

Embodiment 3

[0018] Take the medicinal material of Schisandra chinensis and add 7 times the weight of Schisandra chinensis to extract in water for 1.5 hours; filter, discard the filtrate, dry the dregs at 65°C until the weight is reduced by 20%, crush the dried dregs roughly, and then extract with 70% ethanol under reflux 2 times, each time the amount of ethanol is 8 times the weight of the coarsely crushed medicinal residues, and each extraction is 0.8 hours; filter, combine the filtrate, and concentrate under reduced pressure (70°C, -0.07Mpa) to 60°C with a relative density of 1.32. Paste, take 1.125g of Schizandrin extract (calculated as schisandrin A), add it into 24.4g of molten polyethylene glycol 6000, mix well, raise the temperature to a dripping temperature of 91°C, and drop into liquid paraffin at 7°C After forming, drain the liquid paraffin to get it.

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Abstract

The invention provides a five-ester dropping pill and a preparation method thereof. The five-ester dropping pill is prepared by the following components in parts by weight: 1.125 parts of kadsura longepedunculata alcoholic extractum, and 22-28 parts of polyethylene glycol. According to the five-ester dropping pill and the preparation method thereof, the proportion of raw materials and auxiliary materials can be optimized by taking kadsura longepedunculata alcoholic extractum as the raw material, polyethylene glycol as the matrix and liquid paraffin as the condensate, not only can the excellent forming property and solubility of the dropping pill be ensured, but also the increase of varieties and usage amount of auxiliary materials can be effectively controlled; the five-ester dropping pill is rapid in drug release, fast to act, and convenient to take and low in price.

Description

Technical field [0001] The invention is a pharmaceutical technology field, especially involving a five -ester drop pill and its preparation method. Background technique [0002] South Wuxi is the dry and mature fruits of the Milan family in Magnolia. It is commonly used in traditional Chinese medicine. It tastes sour, sweet, and warm.It has the effects of convergence and astringent, nourishing qi, and nourishing the kidney.Modern Pharmacology confirms that the main ingredients in the ingredonin derivatives extracted from the fruits of the schisisia seeds in Central China are the schisandrain and its analogs.For those who are rising to metastases, they are currently widely used in the south of the south of the south, which are made of five ester capsules made of raw materials. [0003] Pentate Capsules are widely used to antagonize liver cell damage, improve liver function, reduce serum transposeinase, and enhance the blood concentration of immunosuppressive agents to prevent immu...

Claims

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Application Information

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IPC IPC(8): A61K36/79A61K36/57A61K47/34A61K9/20A61P1/16A61K31/09
Inventor 牛锐
Owner CHENGDU RUNHUATANG PHARMA
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