Wuzhi dropping pills and preparation method thereof

A technology of dripping pills and Schisandra chinensis, which is applied in the field of Wuzhi dripping pills and its preparation, can solve the problems of Wuzhi dropping pills with poor formability and long dissolution time, and achieve good formability and solubility, which is conducive to dissolution, Simple operation effect

Active Publication Date: 2017-01-25
CHENGDU RUNHUATANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in the current industrialized production, the five-ester dripping pills still have the disadvantages of poor formability and long dissolution time.

Method used

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  • Wuzhi dropping pills and preparation method thereof
  • Wuzhi dropping pills and preparation method thereof
  • Wuzhi dropping pills and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take the medicinal material of Schisandra chinensis and add 6.5 times the weight of Schisandra chinensis to extract with water for 1 hour; filter, discard the filtrate, dry the dregs at 60°C until the weight is reduced by 15%, crush the dried dregs roughly, and then extract with 70% ethanol under reflux 1 time, the amount of ethanol is 6 times the weight of the coarsely crushed medicinal residues, and the extraction is 0.5 hours each time; filter, combine the filtrate, and concentrate under reduced pressure (70°C, -0.07Mpa) to 60°C with a relative density of 1.25. Paste, take 1.125g of Schizandrin extract (calculated as schisandrin A), add it to 22g of molten polyethylene glycol 6000, mix well, raise the temperature to a dropping temperature of 90°C, and drop it into liquid paraffin at 5°C , after molding, drain the liquid paraffin, that is.

Embodiment 2

[0016] Take the medicinal material of Schisandra chinensis and add 7 times the weight of Schisandra chinensis to extract in water for 1.5 hours; filter, discard the filtrate, dry the dregs at 65°C until the weight is reduced by 15%, crush the dried dregs roughly, and then extract with 70% ethanol under reflux 2 times, each time the amount of ethanol is 7 times the weight of the coarsely crushed medicinal residues, and each extraction is 0.7 hours; filter, combine the filtrates, and concentrate under reduced pressure (70°C, -0.07Mpa) to 60°C with a relative density of 1.31. Paste, take 1.125g of Schizandrin extract (calculated as schisandrin A), add it to 24.4g of molten polyethylene glycol 6000, mix well, raise the temperature to 91°C, drop into liquid paraffin at 6°C After forming, drain the liquid paraffin to get it.

Embodiment 3

[0018] Take the medicinal material of Schisandra chinensis and add 7 times the weight of Schisandra chinensis to extract in water for 1.5 hours; filter, discard the filtrate, dry the dregs at 65°C until the weight is reduced by 20%, crush the dried dregs roughly, and then extract with 70% ethanol under reflux 2 times, each time the amount of ethanol is 8 times the weight of the coarsely crushed medicinal residues, and each extraction is 0.8 hours; filter, combine the filtrate, and concentrate under reduced pressure (70°C, -0.07Mpa) to 60°C with a relative density of 1.32. Paste, take 1.125g of Schizandrin extract (calculated as schisandrin A), add it into 24.4g of molten polyethylene glycol 6000, mix well, raise the temperature to a dripping temperature of 91°C, and drop into liquid paraffin at 7°C After forming, drain the liquid paraffin to get it.

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Abstract

The invention provides a five-ester dropping pill and a preparation method thereof. The five-ester dropping pill is prepared by the following components in parts by weight: 1.125 parts of kadsura longepedunculata alcoholic extractum, and 22-28 parts of polyethylene glycol. According to the five-ester dropping pill and the preparation method thereof, the proportion of raw materials and auxiliary materials can be optimized by taking kadsura longepedunculata alcoholic extractum as the raw material, polyethylene glycol as the matrix and liquid paraffin as the condensate, not only can the excellent forming property and solubility of the dropping pill be ensured, but also the increase of varieties and usage amount of auxiliary materials can be effectively controlled; the five-ester dropping pill is rapid in drug release, fast to act, and convenient to take and low in price.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a five-ester dripping pill and a preparation method thereof. Background technique [0002] Schisandra chinensis is the dry and mature fruit of Schisandra chinensis of the Magnoliaceae plant. It is a commonly used traditional Chinese medicine with a sour, sweet and warm nature. It has the effects of astringent and astringent, nourishing qi and promoting body fluid, invigorating the kidney and calming the heart. Modern pharmacology has confirmed that the main components of the lignan derivatives extracted from the fruit of Schisandra chinensis are schisandrin and its analogues, which have the effect of reducing serum alanine aminotransferase and can be used for alanine aminotransferase in chronic hepatitis. For those with elevated transferase, Wuzhi capsules, which are made from schisandrin extract as raw materials, are widely used clinically. [0003] Wuzhi Capsules...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/79A61K36/57A61K47/34A61K9/20A61P1/16A61K31/09
Inventor 牛锐
Owner CHENGDU RUNHUATANG PHARMA
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