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Application of tree peony bark extract to preparation of skin whitening composition for external use and preparation method of tree peony bark extract

A kind of technology of Moutan Cortex extract and composition, which is applied in the field of whitening composition and skin whitening, and can solve the problems that the crude extract of Moutan Cortex has not been reported.

Inactive Publication Date: 2014-06-25
SHANGHAI INOHERB COSMETIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of Moutan cortex crude extract in whitening cosmetics has not been reported.

Method used

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  • Application of tree peony bark extract to preparation of skin whitening composition for external use and preparation method of tree peony bark extract
  • Application of tree peony bark extract to preparation of skin whitening composition for external use and preparation method of tree peony bark extract
  • Application of tree peony bark extract to preparation of skin whitening composition for external use and preparation method of tree peony bark extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: the preparation of Cortex Moutan Extract

[0038] Take the peony bark, wash it, dry it, remove impurities, and set it aside.

[0039] (1) Weigh a certain amount of Cortex Moutan, extract with 20 times the amount of 90% ethanol aqueous solution, and extract at 70-90°C for 4-6 hours. The extract is left to stand, filtered, concentrated, and dried until the solvent is completely evaporated. Obtain the crude extract of Cortex Moutan (extract A);

[0040] (2) After the extract is dispersed in water, use a macroporous adsorption resin column for separation and purification, sequentially use 4 times the volume of the resin column with water, 3 times the volume of the resin column with an ethanol solution with a volume fraction of 30%, and 3 times the volume of the resin column with The volume fraction is 60% ethanol aqueous solution and the volume fraction of 3 times of the resin column volume is 90% ethanol aqueous solution to carry out elution, collects the el...

Embodiment 2

[0064] Embodiment 2: the preparation of Cortex Moutan Extract

[0065] Take the peony bark, wash it, dry it, remove impurities, and set it aside.

[0066] (1) Weigh a certain amount of Cortex Moutan, extract with 25 times the amount of 80% ethanol aqueous solution, and extract at 80-90°C for 5-7 hours. The extract is left to stand, filtered, concentrated, and dried until the solvent is completely evaporated. Obtain the crude extract of Cortex Moutan;

[0067] (2) After the extract is dispersed in water, use a macroporous adsorption resin column for separation and purification, and then use 3 times the volume of the resin column in water, 2 times the volume of the resin column in an aqueous ethanol solution with a volume fraction of 35%, and 3.5 times the volume of the resin column in water. The volume fraction is 55% ethanol aqueous solution and the volume fraction of 2.5 times of the resin column volume is 92% ethanol aqueous solution for elution, respectively collects the e...

Embodiment 3

[0068] Embodiment 3: the preparation of Cortex Moutan Extract

[0069] Take the peony bark, wash it, dry it, remove impurities, and set it aside.

[0070] (1) Weigh a certain amount of Cortex Moutan, extract with 15 times the amount of 95% ethanol aqueous solution, and extract at 70-80°C for 3-5 hours. The extract is left to stand, filtered, concentrated, and dried until the solvent is completely evaporated. Obtain the crude extract of Cortex Moutan (extract A);

[0071] (2) After the extract is dispersed in water, use a macroporous adsorption resin column for separation and purification, and then use 3.5 times the volume of the resin column with water, 2.5 times the volume of the resin column with an ethanol solution with a volume fraction of 25%, and 2.5 times the volume of the resin column with water. Elute with 65% ethanol aqueous solution and 3.5 times the volume fraction of the resin column volume with 88% ethanol aqueous solution, collect the eluate from each part resp...

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Abstract

The invention relates to an application of a tree peony bark extract to preparation of a skin whitening composition for external use and a preparation method of the tree peony bark extract. The tree peony bark extract contains a component for inhibiting tyrosinase. The preparation method of the tree peony bark extract comprises the steps of extracting tree peony barks by using an organic alcohol water solution to obtain an extracting solution; concentrating the extracting solution, and drying to obtain a crude extract; dispersing the crude extract by using water to form a suspension liquid, separating and purifying the suspension liquid by using macroporous resin, and eluting many times to obtain an eluant; concentrating the eluant, and drying to obtain the tree peony bark extract. The tree peony bark extract obtained by using the preparation method provided by the invention plays a skin whitening role through inhibiting the activity of tyrosinase and further inhibiting the generation of melanin, also has certain stability and can be used for preparing a composition for external use.

Description

technical field [0001] The present invention relates to the use of the extract of Paeoniasuffruticosa, especially its use for skin whitening, a preparation method of the extract of Paeoniasuffruticosa, and a whitening composition comprising the extract of Paeoniasuffruticosa. Background technique [0002] Melanin is a high-molecular-weight biopigment that can block ultraviolet rays, thereby protecting the skin from ultraviolet rays. There are currently three known types, namely Eumelanin, Pheomelanin and Neuromelanin, and the melanin usually referred to is eumelanin. When the skin is irradiated by ultraviolet rays, a large amount of melanin will be produced in the body to protect the skin. The content of melanin is an important factor affecting the depth of skin color. The more melanin you have, the darker your skin will be. Therefore, substances that can inhibit the production of melanin are considered to have the effect of whitening the skin. [0003] Tyrosinase is a p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61Q19/02
Inventor 王鞠骏雷杨符移才胡国胜
Owner SHANGHAI INOHERB COSMETIC
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