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Multifunctional composite medicine table preparation method based on three-dimensional printing and product prepared by using method

A technology of 3D printing and 3D printing, which is applied in the direction of pill delivery, etc. It can solve the problems of inconsistent number of tablets taken at one time, excessive drug release in tablets, and single function of tablets, so as to achieve convenience for users, reduce the number of medications, and simple operation convenient effect

Active Publication Date: 2014-06-25
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Another technical problem to be solved by the present invention is to provide a new type of multifunctional composite tablet based on three-dimensional printing, which has multiple A curative effect, controllable drug release in tablets, etc.

Method used

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  • Multifunctional composite medicine table preparation method based on three-dimensional printing and product prepared by using method
  • Multifunctional composite medicine table preparation method based on three-dimensional printing and product prepared by using method
  • Multifunctional composite medicine table preparation method based on three-dimensional printing and product prepared by using method

Examples

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Comparison scheme
Effect test

Embodiment 1

[0045] like figure 2 As shown, the extrusion three-dimensional printer is taken as an example here, and the tablet preparation process of the present invention is described in detail by using the simplest structure and two kinds of medicines. In the multi-nozzle 3D printer used, the nozzle 3 moves in a plane, and the worktable 2 moves up and down along the Z-axis motion platform 4. The nozzles 3 can be connected to the same two-dimensional motion platform 1, or can be controlled by a two-dimensional motion platform independently. . The inner diameter of the nozzle 3 is 100 μm, the distance between the bottom surface of the nozzle and the working surface is kept at 1 times the inner diameter of the nozzle, and the moving speed of the nozzle is 5 mm / s.

[0046] As shown in Figure 3, prepare the "layered" cylindrical tablet shown in Figure 3(a), as shown in Figure 3(b), the preparation process is as follows:

[0047] like figure 1 As shown, step (1): According to the type of ...

Embodiment 2

[0053] Here, taking an extrusion-type three-dimensional printer as an example, the tablet preparation process of the present invention is described in detail by using the simplest structure and two kinds of medicines.

[0054] As shown in Figure 4, prepare the "enclosed" cuboid-shaped tablet shown in Figure 4(a), as shown in Figure 4(b), the preparation process is as follows:

[0055] Step (1), according to the type of drug and drug content, use CAD software to design the three-dimensional structure model of the tablet, the structure is shown in Figure 4 (a), and the three-dimensional model we designed for Tylenol and cephradine is a "surrounding" cuboid Shaped tablets, the specification is 8mm×5mm×6mm, four-layer structure of inner and outer workers, the outer diameter of the outermost layer is 8mm×5mm×6mm, the thickness is uniform, and the thickness is 0.5; the outer diameter of the second layer is 7mm×4mm ×5mm, the thickness is uniform, the thickness is 0.5; the outer diame...

Embodiment 3

[0061] Here, taking an extrusion-type three-dimensional printer as an example, the tablet preparation process of the present invention is described in detail by using the simplest structure and two kinds of medicines.

[0062] As shown in Figure 5, prepare the cylindrical tablet of the "layer type and enveloping type" shown in Figure 5(a), as shown in Figure 5(b), the preparation process is as follows:

[0063] Step (1): According to the type of drug and drug content, use CAD software to design the three-dimensional structure model of the tablet. The structure is shown in Figure 5 (a). For Tylenol and Cephradine, we use CAD software to design the three-dimensional structure model of the tablet , is a mixed layer structure, in which the whole is cylindrical, with a diameter of 6mm and a height of 8mm; the outermost layer is the first layer, which is a cylindrical surrounding structure, and the outer layer has a diameter of 6mm, a height of 8mm, and a layer thickness of is 0.5mm...

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Abstract

The invention discloses a multifunctional composite medicine table preparation method based on three-dimensional printing. The method comprises the following steps: (1) collecting one or more medicines with synergic treatment effects on one disease, and recording relevant information of each medicine; (2) confirming the structure of a composite tablet according to the obtained information of the medicines, thus obtaining processing codes of a three-dimensional printer by using three-dimensional software; (3) aiming at each medicine, confirming a hydrogel system, and respectively configuring a hydrogel solution of the medicine; and (4) respectively injecting the hydrogel solution into corresponding nozzles of the three-dimensional printer for three-dimensional printing, and after the printing, fixing the shape, thereby obtaining the multifunctional composite tablet. The invention further discloses the tablet prepared by using the method. The table disclosed by the invention is made based on the three-dimensional printer and is high in production efficiency and simple and convenient to operate; tablets, which are made of multiple combined medicines, of different shapes, different structures and different medicine loading capacities can be produced, the flexibility degree is high, and personalized customization can be met.

Description

technical field [0001] The invention belongs to the technical field of drug design, and in particular relates to a preparation method and product of a multifunctional composite tablet based on three-dimensional printing. Background technique [0002] When people are alive, they will get sick more or less, such as cold, cough, inflammation and other symptoms, especially for those with weak physical fitness, such as children, they need to go to the hospital to see a doctor at this time, and only need some medicine for mild illness. Others need drips. The most common one is dispensing medicines. Many people don’t want the pain caused by IV drips, and some people don’t have so much time to stay in the hospital for IV drips. Sometimes it’s just a minor illness. People who see the doctor just do it for prevention or take medicine. . But often when one gets sick, the doctor will prescribe several different medicines to the patient. Each medicine has its own unique curative effect...

Claims

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Application Information

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IPC IPC(8): A61K9/24
Inventor 贺永邵惠锋傅建中苟中入刘安
Owner ZHEJIANG UNIV