Deuterated triazolam and preparation method thereof

Abstract

The invention discloses a deuterated triazolam and a preparation method thereof. The preparation method of the deuterated triazolam comprises the following steps: (1) adding 8-chlorin-6-(2-chlorphenyl)-1-methyl-4H-[1, 2, 4] triazole [4,3-alpha][1,4] benzodiazepine into dimethyl sulfoxide or N, N-dimethylformamide to be mixed and stirred; (2) adding cesium carbonate or potassium carbonate as a catalyst, and adding deuterated chloroform to heat to be higher than 40 DEG C and stirring; (3) separating the deuterated chloroform to obtain the deuterated triazolam. The preparation method is simple, simple and convenient to operate, low in cost and easy to purify; by adopting the commercially available deuterated triazolam in a non-deuterated solvent atmosphere, a small quantity of deuterated reagent is taken as a deuterium source to obtain the deuterated triazolam in a short time; the deuterated triazolam is purified through simple column chromatography to obtain a pure product. The deuterated triazolam standard products prepared by the preparation method are high in purity and stable in chemical properties, and the deuterated triazolam can be conveniently used for preparing analysis standard products. The preparation method can be used for producing deuterated internal standard substance for analyzing and detecting triazolam.

Description

technical field [0001] The invention relates to the field of chemical analysis and detection, in particular to a deuterated triazolam standard product and a preparation method thereof. Background technique [0002] Triazolam is a benzodiazepine central nervous system depressant, which can cause inhibition of different parts of the central nervous system. As the dosage increases, the clinical manifestations can range from mild sedation to hypnosis or even coma. In recent years, criminal cases such as poisoning, suicide, and misuse caused by such drugs have occurred from time to time. This requires the public security judicial appraisal department to test the samples of samples involving such drugs. The means to ensure that the detection method is accurate and reliable is to add an internal standard during detection, and deuterium is the best internal standard. Because its use is non-civilian, it has particularity. For this reason, in our country, for this kind of standard Th...

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Problems solved by technology

The means to ensure that the detection method is accurate and reliable is to add an internal standard during detection, and deuterium is the best internal standard. Because its use is non-civilian, it has particularity. For this reason, in our country, for this kind of standard There are relatively few researches and productions, and such standard products are necessary and indispensable in analysis and detection. For a long time, the deuterated internal standards used in my country have been dependent on imports. The wide use of such standard products in China

[0003] The method reported in the literature selects deuterated sodium hydroxide and expensive deuterated methanol as the deuterium source and reaction medium that are easy to absorb water and deteriorate, and even selects a very strong organic base of potassium tert-butoxide. This method has harsh conditions and relatively low cost. Expensive, cumbersome operation and other disadvantages

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