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Application of steroid compounds in preparation of antitumor chemotherapy drug synergists

A technology of steroidal compounds and chemotherapeutic drugs, which is applied in the application field of steroidal compounds in the preparation of synergists of anti-tumor chemotherapeutic drugs, and can solve the problems of variable component composition and unexplained measured component ratios, etc.

Active Publication Date: 2014-07-02
广州中医药大学热带医学研究所
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Problems solved by technology

It should be pointed out that: due to the existence of compounds with the same molecular weight but different structures in the light dispersion, in the absence of known compounds for comparison, component separation and NMR analysis, the HPLC / MS method obtained in the literature There are variables in the composition of the ingredients; and the proportion of the measured ingredients to the chloroform solubles is not stated, and no pharmacological studies have been conducted on the said monomer ingredients of Tongguangscatter

Method used

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  • Application of steroid compounds in preparation of antitumor chemotherapy drug synergists
  • Application of steroid compounds in preparation of antitumor chemotherapy drug synergists
  • Application of steroid compounds in preparation of antitumor chemotherapy drug synergists

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Embodiment Construction

[0024] Steroid derivatives with the chemical structure and skeleton characteristics of aglycon B (general formula such as figure 1 shown) can be prepared and characterized according to existing techniques, including but not limited to:

[0025] Miyakawa S, et al.Phytochemistry, 1986,25:2861-2865; Luo SQ, et al.Phytochemistry, 1993,34:1615-1620; Qiu SX, et al.Phytochemistry, 1996,41:1385-1388; Jiang Yi , et al. Chinese Journal of Pharmaceutical Industry, 1996,27:391-395; Chen JJ, et al.Acta Botanica Yunnanica,1999,21:369-377; Deng J, et al.Phytochemistry, 2005,66:1040-1051; Hu Yingjie, et al. China Invention Patent, 2009, patent number: ZL200610037029.2.

[0026] Hereinafter, the preparation and structural characterization of some steroid derivatives having the chemical structure skeleton characteristics of light-transmitting aglycon B will be exemplarily described.

[0027] Separation and structural identification of Tongguangsan extract and its monomer components M-6, M-7, ...

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Abstract

The present invention discloses an application of steroid compounds in preparation of antitumor chemotherapy drug synergists. According to the present invention, pharmacological studies at a cell model and nude mice model level is performed, and paclitaxel is adopted the representative drug of anticancer drugs, such that it is found that the steroid compounds having a Tenacigenin B chemical structure skeleton have significant in vitro and in vivo anticancer drug synergy effects, and can be adopted as the bulk drugs for developing the cancer chemotherapy drug synergists with characteristics of clear structure and significant treatment effect.

Description

technical field [0001] The present invention relates to a new application of a class of compounds, in particular to the application of steroid derivatives with the chemical structure and skeleton characteristics of luciferase aglycon B in the preparation of synergists of anti-tumor chemotherapeutic drugs. Background technique [0002] Chemotherapeutic drugs play an important role in the treatment of malignant tumors, but the problems of toxic side effects and drug resistance arising from the chemical structure of tumor chemotherapeutic drugs are difficult to solve. On the one hand, most chemotherapeutic drugs have different degrees of toxic and side effects. While inhibiting tumors, they also have different degrees of killing effects on normal human cells; on the other hand, the drug resistance of tumor cells to drugs is acquired. It is a huge obstacle to the ideal curative effect. The main reason for the failure of chemotherapy for malignant tumors is the drug resistance th...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61K31/7048A61P35/00
Inventor 胡英杰沈小玲符林春艾香英田汝华朱瑞静戴琳玲张艳平
Owner 广州中医药大学热带医学研究所
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